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Functional polarity is introduced by Dicer processing of short substrate RNAs

Synthetic RNA duplexes that are substrates for Dicer are potent triggers of RNA interference (RNAi). Blunt 27mer duplexes can be up to 100-fold more potent than traditional 21mer duplexes (1). Not all 27mer duplexes show increased potency. Evaluation of the products of in vitro dicing reactions usin...

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Detalles Bibliográficos
Autores principales:	Rose, Scott D., Kim, Dong-Ho, Amarzguioui, Mohammed, Heidel, Jeremy D., Collingwood, Michael A., Davis, Mark E., Rossi, John J., Behlke, Mark A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180746/ https://www.ncbi.nlm.nih.gov/pubmed/16049023 http://dx.doi.org/10.1093/nar/gki732

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