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A novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles

Retroviral integration is central to viral persistence and pathogenesis, cancer as well as host genome evolution. However, it is unclear why integration appears essential for retrovirus production, especially given the abundance and transcriptional potential of non-integrated viral genomes. The invo...

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Detalles Bibliográficos
Autores principales:	Delelis, Olivier, Petit, Caroline, Leh, Herve, Mbemba, Gladys, Mouscadet, Jean-François, Sonigo, Pierre
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180852/ https://www.ncbi.nlm.nih.gov/pubmed/15904533 http://dx.doi.org/10.1186/1742-4690-2-31

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