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The impact of illness in patients with moderate to severe gastro-esophageal reflux disease

BACKGROUND: Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GERD is not well known. METHODS: We analyzed data from 217 patients with moderate...

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Autores principales: El-Dika, Samer, Guyatt, Gordon H, Armstrong, David, Degl'innocenti, Alessio, Wiklund, Ingela, Fallone, Carlo A, Tanser, Lisa, van Zanten, Sander Veldhuyzen, Heels-Ansdell, Diane, Wahlqvist, Peter, Chiba, Naoki, Barkun, Alan N, Austin, Peggy, Schünemann, Holger J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183201/
https://www.ncbi.nlm.nih.gov/pubmed/16004616
http://dx.doi.org/10.1186/1471-230X-5-23
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author El-Dika, Samer
Guyatt, Gordon H
Armstrong, David
Degl'innocenti, Alessio
Wiklund, Ingela
Fallone, Carlo A
Tanser, Lisa
van Zanten, Sander Veldhuyzen
Heels-Ansdell, Diane
Wahlqvist, Peter
Chiba, Naoki
Barkun, Alan N
Austin, Peggy
Schünemann, Holger J
author_facet El-Dika, Samer
Guyatt, Gordon H
Armstrong, David
Degl'innocenti, Alessio
Wiklund, Ingela
Fallone, Carlo A
Tanser, Lisa
van Zanten, Sander Veldhuyzen
Heels-Ansdell, Diane
Wahlqvist, Peter
Chiba, Naoki
Barkun, Alan N
Austin, Peggy
Schünemann, Holger J
author_sort El-Dika, Samer
collection PubMed
description BACKGROUND: Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GERD is not well known. METHODS: We analyzed data from 217 patients with moderate to severe GERD (mean age 50, SD 13.7) across 17 Canadian centers. Patients completed three utility instruments – the standard gamble (SG), the feeling thermometer (FT), and the Health Utilities Index 3 (HUI 3) – and several HRQL instruments, including Quality of Life in Reflux and Dyspepsia (QOLRAD) and the Medical Outcomes Short Form-36 (SF-36). All patients received a proton pump inhibitor, esomeprazole 40 mg daily, for four to six weeks. RESULTS: The mean scores on a scale from 0 (dead) to 1 (full health) obtained for the FT, SG, and HUI 3 were 0.67 (95% CI, 0.64 to 0.70), 0.76 (95% CI, 0.75 to 0.80), and 0.80 (95% CI, 0.77 to 0.82) respectively. The mean scores on the SF-36 were lower than the previously reported Canadian and US general population mean scores and work productivity was impaired. CONCLUSION: GERD has significant impact on utility scores, HRQL, and work productivity in patients with moderate to severe disease. Furthermore, the FT and HUI 3 provide more valid measurements of HRQL in GERD than the SG. After treatment with esomeprazole, patients showed improved HRQL.
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spelling pubmed-11832012005-08-06 The impact of illness in patients with moderate to severe gastro-esophageal reflux disease El-Dika, Samer Guyatt, Gordon H Armstrong, David Degl'innocenti, Alessio Wiklund, Ingela Fallone, Carlo A Tanser, Lisa van Zanten, Sander Veldhuyzen Heels-Ansdell, Diane Wahlqvist, Peter Chiba, Naoki Barkun, Alan N Austin, Peggy Schünemann, Holger J BMC Gastroenterol Research Article BACKGROUND: Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GERD is not well known. METHODS: We analyzed data from 217 patients with moderate to severe GERD (mean age 50, SD 13.7) across 17 Canadian centers. Patients completed three utility instruments – the standard gamble (SG), the feeling thermometer (FT), and the Health Utilities Index 3 (HUI 3) – and several HRQL instruments, including Quality of Life in Reflux and Dyspepsia (QOLRAD) and the Medical Outcomes Short Form-36 (SF-36). All patients received a proton pump inhibitor, esomeprazole 40 mg daily, for four to six weeks. RESULTS: The mean scores on a scale from 0 (dead) to 1 (full health) obtained for the FT, SG, and HUI 3 were 0.67 (95% CI, 0.64 to 0.70), 0.76 (95% CI, 0.75 to 0.80), and 0.80 (95% CI, 0.77 to 0.82) respectively. The mean scores on the SF-36 were lower than the previously reported Canadian and US general population mean scores and work productivity was impaired. CONCLUSION: GERD has significant impact on utility scores, HRQL, and work productivity in patients with moderate to severe disease. Furthermore, the FT and HUI 3 provide more valid measurements of HRQL in GERD than the SG. After treatment with esomeprazole, patients showed improved HRQL. BioMed Central 2005-07-10 /pmc/articles/PMC1183201/ /pubmed/16004616 http://dx.doi.org/10.1186/1471-230X-5-23 Text en Copyright © 2005 El-Dika et al; licensee BioMed Central Ltd.
spellingShingle Research Article
El-Dika, Samer
Guyatt, Gordon H
Armstrong, David
Degl'innocenti, Alessio
Wiklund, Ingela
Fallone, Carlo A
Tanser, Lisa
van Zanten, Sander Veldhuyzen
Heels-Ansdell, Diane
Wahlqvist, Peter
Chiba, Naoki
Barkun, Alan N
Austin, Peggy
Schünemann, Holger J
The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
title The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
title_full The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
title_fullStr The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
title_full_unstemmed The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
title_short The impact of illness in patients with moderate to severe gastro-esophageal reflux disease
title_sort impact of illness in patients with moderate to severe gastro-esophageal reflux disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183201/
https://www.ncbi.nlm.nih.gov/pubmed/16004616
http://dx.doi.org/10.1186/1471-230X-5-23
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