Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients

BACKGROUND: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parki...

Descripción completa

Detalles Bibliográficos
Autores principales: Clarimon, Jordi, Xiromerisiou, Georgia, Eerola, Johanna, Gourbali, Vanesa, Hellström, Olli, Dardiotis, Euthimios, Peuralinna, Terhi, Papadimitriou, Alexandros, Hadjigeorgiou, George M, Tienari, Pentti J, Singleton, Andrew B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183215/
https://www.ncbi.nlm.nih.gov/pubmed/15967032
http://dx.doi.org/10.1186/1471-2377-5-11
Descripción
Sumario:BACKGROUND: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. METHODS: Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. RESULTS: No association was found in any of the populations studied. CONCLUSION: Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.

Ejemplares similares