Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients

BACKGROUND: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parki...

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Autores principales: Clarimon, Jordi, Xiromerisiou, Georgia, Eerola, Johanna, Gourbali, Vanesa, Hellström, Olli, Dardiotis, Euthimios, Peuralinna, Terhi, Papadimitriou, Alexandros, Hadjigeorgiou, George M, Tienari, Pentti J, Singleton, Andrew B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
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Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183215/
https://www.ncbi.nlm.nih.gov/pubmed/15967032
http://dx.doi.org/10.1186/1471-2377-5-11
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author Clarimon, Jordi
Xiromerisiou, Georgia
Eerola, Johanna
Gourbali, Vanesa
Hellström, Olli
Dardiotis, Euthimios
Peuralinna, Terhi
Papadimitriou, Alexandros
Hadjigeorgiou, George M
Tienari, Pentti J
Singleton, Andrew B
author_facet Clarimon, Jordi
Xiromerisiou, Georgia
Eerola, Johanna
Gourbali, Vanesa
Hellström, Olli
Dardiotis, Euthimios
Peuralinna, Terhi
Papadimitriou, Alexandros
Hadjigeorgiou, George M
Tienari, Pentti J
Singleton, Andrew B
author_sort Clarimon, Jordi
collection PubMed
description BACKGROUND: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. METHODS: Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. RESULTS: No association was found in any of the populations studied. CONCLUSION: Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.
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spelling pubmed-11832152005-08-06 Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients Clarimon, Jordi Xiromerisiou, Georgia Eerola, Johanna Gourbali, Vanesa Hellström, Olli Dardiotis, Euthimios Peuralinna, Terhi Papadimitriou, Alexandros Hadjigeorgiou, George M Tienari, Pentti J Singleton, Andrew B BMC Neurol Research Article BACKGROUND: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson's disease (PD). Our aim was to replicate this association in two independent populations. METHODS: Allelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland. RESULTS: No association was found in any of the populations studied. CONCLUSION: Taken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations. BioMed Central 2005-06-20 /pmc/articles/PMC1183215/ /pubmed/15967032 http://dx.doi.org/10.1186/1471-2377-5-11 Text en Copyright © 2005 Clarimon et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Clarimon, Jordi
Xiromerisiou, Georgia
Eerola, Johanna
Gourbali, Vanesa
Hellström, Olli
Dardiotis, Euthimios
Peuralinna, Terhi
Papadimitriou, Alexandros
Hadjigeorgiou, George M
Tienari, Pentti J
Singleton, Andrew B
Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
title Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
title_full Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
title_fullStr Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
title_full_unstemmed Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
title_short Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients
title_sort lack of evidence for a genetic association between fgf20 and parkinson's disease in finnish and greek patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183215/
https://www.ncbi.nlm.nih.gov/pubmed/15967032
http://dx.doi.org/10.1186/1471-2377-5-11
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