Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp

BACKGROUND: The tetrodotoxin-resistant voltage-gated sodium channel Na(v)1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. METHODS: Using specific antibodies for immunohistochemistry, we studied Na(v)1.8 – immunoreactivity in human dental pulp in relation to the neuronal...

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Detalles Bibliográficos
Autores principales: Renton, T, Yiangou, Y, Plumpton, C, Tate, S, Bountra, C, Anand, P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183220/
https://www.ncbi.nlm.nih.gov/pubmed/16001984
http://dx.doi.org/10.1186/1472-6831-5-5
Descripción
Sumario:BACKGROUND: The tetrodotoxin-resistant voltage-gated sodium channel Na(v)1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. METHODS: Using specific antibodies for immunohistochemistry, we studied Na(v)1.8 – immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain). RESULTS: Fibres immunoreactive for Na(v)1.8, were significantly increased on image analysis in the painful group: median (range) Na(v)1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006–0.24), painful 0.265 (0.13–0.5), P = 0.0019. CONCLUSION: Na(v)1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states.

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