Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp

BACKGROUND: The tetrodotoxin-resistant voltage-gated sodium channel Na(v)1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. METHODS: Using specific antibodies for immunohistochemistry, we studied Na(v)1.8 – immunoreactivity in human dental pulp in relation to the neuronal...

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Detalles Bibliográficos
Autores principales: Renton, T, Yiangou, Y, Plumpton, C, Tate, S, Bountra, C, Anand, P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183220/
https://www.ncbi.nlm.nih.gov/pubmed/16001984
http://dx.doi.org/10.1186/1472-6831-5-5
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author Renton, T
Yiangou, Y
Plumpton, C
Tate, S
Bountra, C
Anand, P
author_facet Renton, T
Yiangou, Y
Plumpton, C
Tate, S
Bountra, C
Anand, P
author_sort Renton, T
collection PubMed
description BACKGROUND: The tetrodotoxin-resistant voltage-gated sodium channel Na(v)1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. METHODS: Using specific antibodies for immunohistochemistry, we studied Na(v)1.8 – immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain). RESULTS: Fibres immunoreactive for Na(v)1.8, were significantly increased on image analysis in the painful group: median (range) Na(v)1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006–0.24), painful 0.265 (0.13–0.5), P = 0.0019. CONCLUSION: Na(v)1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states.
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spelling pubmed-11832202005-08-06 Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp Renton, T Yiangou, Y Plumpton, C Tate, S Bountra, C Anand, P BMC Oral Health Research Article BACKGROUND: The tetrodotoxin-resistant voltage-gated sodium channel Na(v)1.8 (SNS1/PN3) is expressed by nociceptors and may play a role in pain states. METHODS: Using specific antibodies for immunohistochemistry, we studied Na(v)1.8 – immunoreactivity in human dental pulp in relation to the neuronal marker neurofilament. Human tooth pulp was extracted from teeth harvested from a total of twenty-two patients (fourteen without dental pain, eight patients with dental pain). RESULTS: Fibres immunoreactive for Na(v)1.8, were significantly increased on image analysis in the painful group: median (range) Na(v)1.8 to Neurofilament % area ratio, non-painful 0.059 (0.006–0.24), painful 0.265 (0.13–0.5), P = 0.0019. CONCLUSION: Na(v)1.8 sodium channels may thus represent a therapeutic target in trigeminal nerve pain states. BioMed Central 2005-07-07 /pmc/articles/PMC1183220/ /pubmed/16001984 http://dx.doi.org/10.1186/1472-6831-5-5 Text en Copyright © 2005 Renton et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Renton, T
Yiangou, Y
Plumpton, C
Tate, S
Bountra, C
Anand, P
Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
title Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
title_full Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
title_fullStr Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
title_full_unstemmed Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
title_short Sodium channel Na(v)1.8 immunoreactivity in painful human dental pulp
title_sort sodium channel na(v)1.8 immunoreactivity in painful human dental pulp
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183220/
https://www.ncbi.nlm.nih.gov/pubmed/16001984
http://dx.doi.org/10.1186/1472-6831-5-5
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AT plumptonc sodiumchannelnav18immunoreactivityinpainfulhumandentalpulp
AT tates sodiumchannelnav18immunoreactivityinpainfulhumandentalpulp
AT bountrac sodiumchannelnav18immunoreactivityinpainfulhumandentalpulp
AT anandp sodiumchannelnav18immunoreactivityinpainfulhumandentalpulp

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