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Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

BACKGROUND: Multidrug resistance mediated by the multidrug resistance-associated protein 1 (MRP1) decreases cellular drug accumulation. The exact mechanism of MRP1 involved multidrug resistance has not been clarified yet, though glutathione (GSH) is likely to have a role for the resistance to occur....

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Detalles Bibliográficos
Autores principales:	Akan, Ilhan, Akan, Selma, Akca, Hakan, Savas, Burhan, Ozben, Tomris
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183228/ https://www.ncbi.nlm.nih.gov/pubmed/16042792 http://dx.doi.org/10.1186/1475-2867-5-22

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