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A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
BACKGROUND: Subjects with type 2 diabetes are at an increased risk of vascular complications. The use of carotid ultrasound remains an attractive, non-invasive method to monitor atherosclerotic disease progression and/or response to treatment in patients with type 2 diabetes, with intima-media thick...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184090/ https://www.ncbi.nlm.nih.gov/pubmed/15958169 http://dx.doi.org/10.1186/1476-7120-3-15 |
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author | Pollex, Rebecca L Spence, J David House, Andrew A Fenster, Aaron Hanley, Anthony JG Zinman, Bernard Harris, Stewart B Hegele, Robert A |
author_facet | Pollex, Rebecca L Spence, J David House, Andrew A Fenster, Aaron Hanley, Anthony JG Zinman, Bernard Harris, Stewart B Hegele, Robert A |
author_sort | Pollex, Rebecca L |
collection | PubMed |
description | BACKGROUND: Subjects with type 2 diabetes are at an increased risk of vascular complications. The use of carotid ultrasound remains an attractive, non-invasive method to monitor atherosclerotic disease progression and/or response to treatment in patients with type 2 diabetes, with intima-media thickness routinely used as the gold standard to detect pathology. However, alternative measurements, such as plaque area or volume, may represent a potentially more powerful approach. Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes. METHODS: The case-control study included 49 Oji-Cree adults with diabetes or impaired glucose tolerance, aged 21–69, and 49 sex- and age-matched normoglycemic subjects. At baseline, metabolic variables were measured, including body mass index, waist circumference, total cholesterol:high density lipoprotein ratio, plasma triglycerides, plasma glucose, and serum insulin. Carotid ultrasound measurements, 7 years later, assessed carotid arterial intima-media thickness and total plaque volume. RESULTS: At baseline, the two groups were well matched for smoking habits, hypertension, body mass index, and waist circumference. Differences were noted in baseline measurements of total cholesterol:high density lipoprotein (P = 0.0006), plasma triglycerides (P < 0.0001) and fasting glucose (P < 0.0001). After seven years, carotid ultrasound scans revealed that total plaque volume measurements (P = 0.037), but not intima-media thickness measurements, were higher in subjects with diabetes/impaired glucose tolerance compared to the normoglycemic controls. Correlation between intima-media thickness and total plaque volume was moderate. Based on our study findings, to achieve power levels >0.70 when comparing intima-media thickness measurements for diabetics versus non-diabetics, thousands of study subjects are required. For comparing total plaque volume measurements, only hundreds of study subjects are required. CONCLUSION: The development of atherosclerotic plaque is greater in subjects with diabetes/impaired glucose tolerance. Total plaque volume appears to capture the atherosclerotic disease burden more effectively in subjects with type 2 diabetes, and would be an appropriate outcome measure for studies aimed at changing the diabetic milieu. |
format | Text |
id | pubmed-1184090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11840902005-08-11 A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes Pollex, Rebecca L Spence, J David House, Andrew A Fenster, Aaron Hanley, Anthony JG Zinman, Bernard Harris, Stewart B Hegele, Robert A Cardiovasc Ultrasound Research BACKGROUND: Subjects with type 2 diabetes are at an increased risk of vascular complications. The use of carotid ultrasound remains an attractive, non-invasive method to monitor atherosclerotic disease progression and/or response to treatment in patients with type 2 diabetes, with intima-media thickness routinely used as the gold standard to detect pathology. However, alternative measurements, such as plaque area or volume, may represent a potentially more powerful approach. Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes. METHODS: The case-control study included 49 Oji-Cree adults with diabetes or impaired glucose tolerance, aged 21–69, and 49 sex- and age-matched normoglycemic subjects. At baseline, metabolic variables were measured, including body mass index, waist circumference, total cholesterol:high density lipoprotein ratio, plasma triglycerides, plasma glucose, and serum insulin. Carotid ultrasound measurements, 7 years later, assessed carotid arterial intima-media thickness and total plaque volume. RESULTS: At baseline, the two groups were well matched for smoking habits, hypertension, body mass index, and waist circumference. Differences were noted in baseline measurements of total cholesterol:high density lipoprotein (P = 0.0006), plasma triglycerides (P < 0.0001) and fasting glucose (P < 0.0001). After seven years, carotid ultrasound scans revealed that total plaque volume measurements (P = 0.037), but not intima-media thickness measurements, were higher in subjects with diabetes/impaired glucose tolerance compared to the normoglycemic controls. Correlation between intima-media thickness and total plaque volume was moderate. Based on our study findings, to achieve power levels >0.70 when comparing intima-media thickness measurements for diabetics versus non-diabetics, thousands of study subjects are required. For comparing total plaque volume measurements, only hundreds of study subjects are required. CONCLUSION: The development of atherosclerotic plaque is greater in subjects with diabetes/impaired glucose tolerance. Total plaque volume appears to capture the atherosclerotic disease burden more effectively in subjects with type 2 diabetes, and would be an appropriate outcome measure for studies aimed at changing the diabetic milieu. BioMed Central 2005-06-15 /pmc/articles/PMC1184090/ /pubmed/15958169 http://dx.doi.org/10.1186/1476-7120-3-15 Text en Copyright © 2005 Pollex et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Pollex, Rebecca L Spence, J David House, Andrew A Fenster, Aaron Hanley, Anthony JG Zinman, Bernard Harris, Stewart B Hegele, Robert A A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
title | A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
title_full | A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
title_fullStr | A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
title_full_unstemmed | A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
title_short | A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
title_sort | comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184090/ https://www.ncbi.nlm.nih.gov/pubmed/15958169 http://dx.doi.org/10.1186/1476-7120-3-15 |
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