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QT interval prolongation after sertraline overdose: a case report

BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolon...

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Autores principales: de Boer, Rudolf A, van Dijk, Tonnis H, Holman, Nicole D, van Melle, Joost P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1185529/
https://www.ncbi.nlm.nih.gov/pubmed/16029494
http://dx.doi.org/10.1186/1471-227X-5-5
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author de Boer, Rudolf A
van Dijk, Tonnis H
Holman, Nicole D
van Melle, Joost P
author_facet de Boer, Rudolf A
van Dijk, Tonnis H
Holman, Nicole D
van Melle, Joost P
author_sort de Boer, Rudolf A
collection PubMed
description BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolongation after an overdose of the SSRI sertraline. CASE PRESENTATION: A previously healthy female patient presented with an attempted suicide with overdoses sertraline (2250 mg), diazepam (200 mg), and temazepam (400 mg). Routine laboratory studies were normal and her ECG upon admission showed a normal QT interval. The next day, her ECG showed prolongation of the QT(c )interval up to 525 ms. After discontinuation of sertraline the QT interval normalized. Echocardiography and exercise electrocardiography were normal. After hospitalization, the patient resumed sertraline in the normally recommended dose and QT interval remained within normal ranges. CONCLUSION: It seems that the SSRI sertraline in overdose may cause QT interval prolongation.
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spelling pubmed-11855292005-08-13 QT interval prolongation after sertraline overdose: a case report de Boer, Rudolf A van Dijk, Tonnis H Holman, Nicole D van Melle, Joost P BMC Emerg Med Case Report BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolongation after an overdose of the SSRI sertraline. CASE PRESENTATION: A previously healthy female patient presented with an attempted suicide with overdoses sertraline (2250 mg), diazepam (200 mg), and temazepam (400 mg). Routine laboratory studies were normal and her ECG upon admission showed a normal QT interval. The next day, her ECG showed prolongation of the QT(c )interval up to 525 ms. After discontinuation of sertraline the QT interval normalized. Echocardiography and exercise electrocardiography were normal. After hospitalization, the patient resumed sertraline in the normally recommended dose and QT interval remained within normal ranges. CONCLUSION: It seems that the SSRI sertraline in overdose may cause QT interval prolongation. BioMed Central 2005-07-19 /pmc/articles/PMC1185529/ /pubmed/16029494 http://dx.doi.org/10.1186/1471-227X-5-5 Text en Copyright © 2005 de Boer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
de Boer, Rudolf A
van Dijk, Tonnis H
Holman, Nicole D
van Melle, Joost P
QT interval prolongation after sertraline overdose: a case report
title QT interval prolongation after sertraline overdose: a case report
title_full QT interval prolongation after sertraline overdose: a case report
title_fullStr QT interval prolongation after sertraline overdose: a case report
title_full_unstemmed QT interval prolongation after sertraline overdose: a case report
title_short QT interval prolongation after sertraline overdose: a case report
title_sort qt interval prolongation after sertraline overdose: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1185529/
https://www.ncbi.nlm.nih.gov/pubmed/16029494
http://dx.doi.org/10.1186/1471-227X-5-5
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