Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential

BACKGROUND: In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate telomere shortening and cause replicative senescence and apoptotic cell death...

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Detalles Bibliográficos
Autores principales: Shammas, Masood A, Koley, Hemanta, Batchu, Ramesh B, Bertheau, Robert C, Protopopov, Alexei, Munshi, Nikhil C, Goyal, Raj K
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187920/
https://www.ncbi.nlm.nih.gov/pubmed/16022731
http://dx.doi.org/10.1186/1476-4598-4-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187920/
https://www.ncbi.nlm.nih.gov/pubmed/16022731
http://dx.doi.org/10.1186/1476-4598-4-24

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