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Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome

Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HIV infection and was highly expressed in human malignant breast tumors and the ligand for CX...

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Autores principales: Wang, Na, Wu, Qiu-Liang, Fang, Yan, Mai, Hai-Qiang, Zeng, Mu-Sheng, Shen, Guo-Ping, Hou, Jing-Hui, Zeng, Yi-Xin
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188078/
https://www.ncbi.nlm.nih.gov/pubmed/15978137
http://dx.doi.org/10.1186/1479-5876-3-26
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author Wang, Na
Wu, Qiu-Liang
Fang, Yan
Mai, Hai-Qiang
Zeng, Mu-Sheng
Shen, Guo-Ping
Hou, Jing-Hui
Zeng, Yi-Xin
author_facet Wang, Na
Wu, Qiu-Liang
Fang, Yan
Mai, Hai-Qiang
Zeng, Mu-Sheng
Shen, Guo-Ping
Hou, Jing-Hui
Zeng, Yi-Xin
author_sort Wang, Na
collection PubMed
description Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HIV infection and was highly expressed in human malignant breast tumors and the ligand for CXCR4, CXCL12 (SDF-1), exhibited high expression in organs in which breast cancer metastases are often found. The metastatic pattern of NPC is quite similar to that of malignant breast tumors. In this study, we investigated the expression of CXCR4 in nasopharyngeal carcinoma (NPC) tissues by immunohistostaining. We found different staining patterns, which included localization in the nucleus, membrane, cytoplasm or a combination of them. The staining intensity was also variable among samples. The metastatic rates in patients with high compared to low or absent expression was 38.6% versus 19.8%, respectively (P = 0.004). High expression of CXCR4 was associated with poor overall survival (OS = 67.05% versus 82.08%, P = 0.0225). These results suggest that CXCR4 may be involved in the progression of NPC and that a high level of CXCR4 expression could be used as a prognostic factor.
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spelling pubmed-11880782005-08-20 Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome Wang, Na Wu, Qiu-Liang Fang, Yan Mai, Hai-Qiang Zeng, Mu-Sheng Shen, Guo-Ping Hou, Jing-Hui Zeng, Yi-Xin J Transl Med Research Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells and Epstein-Barr virus infection has been reported to be a cause of this disease. Chemokine receptor CXCR4 was found to be involved in HIV infection and was highly expressed in human malignant breast tumors and the ligand for CXCR4, CXCL12 (SDF-1), exhibited high expression in organs in which breast cancer metastases are often found. The metastatic pattern of NPC is quite similar to that of malignant breast tumors. In this study, we investigated the expression of CXCR4 in nasopharyngeal carcinoma (NPC) tissues by immunohistostaining. We found different staining patterns, which included localization in the nucleus, membrane, cytoplasm or a combination of them. The staining intensity was also variable among samples. The metastatic rates in patients with high compared to low or absent expression was 38.6% versus 19.8%, respectively (P = 0.004). High expression of CXCR4 was associated with poor overall survival (OS = 67.05% versus 82.08%, P = 0.0225). These results suggest that CXCR4 may be involved in the progression of NPC and that a high level of CXCR4 expression could be used as a prognostic factor. BioMed Central 2005-06-26 /pmc/articles/PMC1188078/ /pubmed/15978137 http://dx.doi.org/10.1186/1479-5876-3-26 Text en Copyright © 2005 Wang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Wang, Na
Wu, Qiu-Liang
Fang, Yan
Mai, Hai-Qiang
Zeng, Mu-Sheng
Shen, Guo-Ping
Hou, Jing-Hui
Zeng, Yi-Xin
Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
title Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
title_full Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
title_fullStr Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
title_full_unstemmed Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
title_short Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
title_sort expression of chemokine receptor cxcr4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188078/
https://www.ncbi.nlm.nih.gov/pubmed/15978137
http://dx.doi.org/10.1186/1479-5876-3-26
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