Cargando…
Croup Is Associated with the Novel Coronavirus NL63
BACKGROUND: The clinical relevance of infections with the novel human coronavirus NL63 (HCoV-NL63) has not been investigated systematically. We therefore determined its association with disease in young children with lower respiratory tract infection (LRTI). METHODS AND FINDINGS: Nine hundred forty-...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188248/ https://www.ncbi.nlm.nih.gov/pubmed/16104827 http://dx.doi.org/10.1371/journal.pmed.0020240 |
_version_ | 1782124783968714752 |
---|---|
author | van der Hoek, Lia Sure, Klaus Ihorst, Gabriele Stang, Alexander Pyrc, Krzysztof Jebbink, Maarten F Petersen, Gudula Forster, Johannes Berkhout, Ben Überla, Klaus |
author_facet | van der Hoek, Lia Sure, Klaus Ihorst, Gabriele Stang, Alexander Pyrc, Krzysztof Jebbink, Maarten F Petersen, Gudula Forster, Johannes Berkhout, Ben Überla, Klaus |
author_sort | van der Hoek, Lia |
collection | PubMed |
description | BACKGROUND: The clinical relevance of infections with the novel human coronavirus NL63 (HCoV-NL63) has not been investigated systematically. We therefore determined its association with disease in young children with lower respiratory tract infection (LRTI). METHODS AND FINDINGS: Nine hundred forty-nine samples of nasopharyngeal secretions from children under 3 y of age with LRTIs were analysed by a quantitative HCoV-NL63-specific real-time PCR. The samples had been collected from hospitalised patients and outpatients from December 1999 to October 2001 in four different regions in Germany as part of the prospective population-based PRI.DE study and analysed for RNA from respiratory viruses. Forty-nine samples (5.2%), mainly derived from the winter season, were positive for HCoV-NL63 RNA. The viral RNA was more prevalent in samples from outpatients (7.9%) than from hospitalised patients (3.2%, p = 0.003), and co-infection with either respiratory syncytial virus or parainfluenza virus 3 was observed frequently. Samples in which only HCoV-NL63 RNA could be detected had a significantly higher viral load than samples containing additional respiratory viruses (median 2.1 × 10(6) versus 2.7 × 10(2) copies/ml, p = 0.0006). A strong association with croup was apparent: 43% of the HCoV-NL63-positive patients with high HCoV-NL63 load and absence of co-infection suffered from croup, compared to 6% in the HCoV-NL63-negative group, p < 0.0001. A significantly higher fraction (17.4%) of samples from croup patients than from non-croup patients (4.2%) contained HCoV-NL63 RNA. CONCLUSION: HCoV-NL63 infections occur frequently in young children with LRTI and show a strong association with croup, suggesting a causal relationship. |
format | Text |
id | pubmed-1188248 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-11882482005-08-23 Croup Is Associated with the Novel Coronavirus NL63 van der Hoek, Lia Sure, Klaus Ihorst, Gabriele Stang, Alexander Pyrc, Krzysztof Jebbink, Maarten F Petersen, Gudula Forster, Johannes Berkhout, Ben Überla, Klaus PLoS Med Research Article BACKGROUND: The clinical relevance of infections with the novel human coronavirus NL63 (HCoV-NL63) has not been investigated systematically. We therefore determined its association with disease in young children with lower respiratory tract infection (LRTI). METHODS AND FINDINGS: Nine hundred forty-nine samples of nasopharyngeal secretions from children under 3 y of age with LRTIs were analysed by a quantitative HCoV-NL63-specific real-time PCR. The samples had been collected from hospitalised patients and outpatients from December 1999 to October 2001 in four different regions in Germany as part of the prospective population-based PRI.DE study and analysed for RNA from respiratory viruses. Forty-nine samples (5.2%), mainly derived from the winter season, were positive for HCoV-NL63 RNA. The viral RNA was more prevalent in samples from outpatients (7.9%) than from hospitalised patients (3.2%, p = 0.003), and co-infection with either respiratory syncytial virus or parainfluenza virus 3 was observed frequently. Samples in which only HCoV-NL63 RNA could be detected had a significantly higher viral load than samples containing additional respiratory viruses (median 2.1 × 10(6) versus 2.7 × 10(2) copies/ml, p = 0.0006). A strong association with croup was apparent: 43% of the HCoV-NL63-positive patients with high HCoV-NL63 load and absence of co-infection suffered from croup, compared to 6% in the HCoV-NL63-negative group, p < 0.0001. A significantly higher fraction (17.4%) of samples from croup patients than from non-croup patients (4.2%) contained HCoV-NL63 RNA. CONCLUSION: HCoV-NL63 infections occur frequently in young children with LRTI and show a strong association with croup, suggesting a causal relationship. Public Library of Science 2005-08 2005-08-23 /pmc/articles/PMC1188248/ /pubmed/16104827 http://dx.doi.org/10.1371/journal.pmed.0020240 Text en Copyright: © 2005 van der Hoek et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article van der Hoek, Lia Sure, Klaus Ihorst, Gabriele Stang, Alexander Pyrc, Krzysztof Jebbink, Maarten F Petersen, Gudula Forster, Johannes Berkhout, Ben Überla, Klaus Croup Is Associated with the Novel Coronavirus NL63 |
title | Croup Is Associated with the Novel Coronavirus NL63 |
title_full | Croup Is Associated with the Novel Coronavirus NL63 |
title_fullStr | Croup Is Associated with the Novel Coronavirus NL63 |
title_full_unstemmed | Croup Is Associated with the Novel Coronavirus NL63 |
title_short | Croup Is Associated with the Novel Coronavirus NL63 |
title_sort | croup is associated with the novel coronavirus nl63 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188248/ https://www.ncbi.nlm.nih.gov/pubmed/16104827 http://dx.doi.org/10.1371/journal.pmed.0020240 |
work_keys_str_mv | AT vanderhoeklia croupisassociatedwiththenovelcoronavirusnl63 AT sureklaus croupisassociatedwiththenovelcoronavirusnl63 AT ihorstgabriele croupisassociatedwiththenovelcoronavirusnl63 AT stangalexander croupisassociatedwiththenovelcoronavirusnl63 AT pyrckrzysztof croupisassociatedwiththenovelcoronavirusnl63 AT jebbinkmaartenf croupisassociatedwiththenovelcoronavirusnl63 AT petersengudula croupisassociatedwiththenovelcoronavirusnl63 AT forsterjohannes croupisassociatedwiththenovelcoronavirusnl63 AT berkhoutben croupisassociatedwiththenovelcoronavirusnl63 AT uberlaklaus croupisassociatedwiththenovelcoronavirusnl63 |