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Genome-Wide Requirements for Resistance to Functionally Distinct DNA-Damaging Agents
The mechanistic and therapeutic differences in the cellular response to DNA-damaging compounds are not completely understood, despite intense study. To expand our knowledge of DNA damage, we assayed the effects of 12 closely related DNA-damaging agents on the complete pool of ~4,700 barcoded homozyg...
Autores principales: | Lee, William, St.Onge, Robert P, Proctor, Michael, Flaherty, Patrick, Jordan, Michael I, Arkin, Adam P, Davis, Ronald W, Nislow, Corey, Giaever, Guri |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189734/ https://www.ncbi.nlm.nih.gov/pubmed/16121259 http://dx.doi.org/10.1371/journal.pgen.0010024 |
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