Cargando…

Archazolid and apicularen: Novel specific V-ATPase inhibitors

BACKGROUND: V-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a multitude of eukaryotic membranes, they energize many different transport processes. Since their malfunction is correlated with various diseases in humans, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huss, Markus, Sasse, Florenz, Kunze, Brigitte, Jansen, Rolf, Steinmetz, Heinrich, Ingenhorst, Gudrun, Zeeck, Axel, Wieczorek, Helmut
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190152/ https://www.ncbi.nlm.nih.gov/pubmed/16080788 http://dx.doi.org/10.1186/1471-2091-6-13

Ejemplares similares

Anti-leukemic effects of the V-ATPase inhibitor Archazolid A
por: Zhang, Siwei, et al.
Publicado: (2015)

The vacuolar-type ATPase inhibitor archazolid increases tumor cell adhesion to endothelial cells by accumulating extracellular collagen
por: Luong, Betty, et al.
Publicado: (2018)

Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay
por: Martinez, Javier P, et al.
Publicado: (2013)

Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments
por: Vincent, Cooper T., et al.
Publicado: (2019)

Total syntheses of the archazolids: an emerging class of novel anticancer drugs
por: Scheeff, Stephan, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Highly Potent Simplified Archazolids
por: Rivière, Solenne, et al.
Publicado: (2020)

Correction: Suzuki coupling-based synthesis of VATPase inhibitor archazolid natural product derived fragments
por: Vincent, Cooper A., et al.
Publicado: (2019)

PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells
por: Seo, Kang-Sik, et al.
Publicado: (2014)

Biological Activity of Volatiles from Marine and Terrestrial Bacteria
por: Schulz, Stefan, et al.
Publicado: (2010)

Flexibility within the Rotor and Stators of the Vacuolar H(+)-ATPase
por: Song, Chun Feng, et al.
Publicado: (2013)

Structure of the Vacuolar H(+)-ATPase Rotary Motor Reveals New Mechanistic Insights
por: Rawson, Shaun, et al.
Publicado: (2015)

Subunit Positioning and Stator Filament Stiffness in Regulation and Power Transmission in the V(1) Motor of the Manduca sexta V-ATPase()
por: Muench, Stephen P., et al.
Publicado: (2014)

Investigations on the mode of action of gephyronic acid, an inhibitor of eukaryotic protein translation from myxobacteria
por: Muthukumar, Yazh, et al.
Publicado: (2018)

Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations
por: Knobloch, Tobias, et al.
Publicado: (2012)

Preparation of new alkyne-modified ansamitocins by mutasynthesis
por: Harmrolfs, Kirsten, et al.
Publicado: (2014)

Myxobacteria: natural pharmaceutical factories
por: Diez, Juana, et al.
Publicado: (2012)

PA1b Inhibitor Binding to Subunits c and e of the Vacuolar ATPase Reveals Its Insecticidal Mechanism
por: Muench, Stephen P., et al.
Publicado: (2014)

V-ATPases and osteoclasts: ambiguous future of V-ATPases inhibitors in osteoporosis
por: Duan, Xiaohong, et al.
Publicado: (2018)

Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum
por: Kunze, Brigitte, et al.
Publicado: (2010)

The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway
por: Fleta-Soriano, Eric, et al.
Publicado: (2014)

V-ATPase-Mediated Granular Acidification Is Regulated by the V-ATPase Accessory Subunit Ac45 in POMC-Producing Cells
por: Jansen, Eric J. R., et al.
Publicado: (2010)

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
por: Firestone, Ari J., et al.
Publicado: (2012)

Novel Inhibitors of E. coli RecA ATPase Activity
por: Sexton, Jonathan Z, et al.
Publicado: (2010)

Binding of the Inhibitor Protein IF(1) to Bovine F(1)-ATPase
por: Bason, John V., et al.
Publicado: (2011)

Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97
por: LaPorte, Matthew G., et al.
Publicado: (2018)

The F1Fo-ATPase inhibitor protein IF1 in pathophysiology
por: Gatto, Cristina, et al.
Publicado: (2022)

Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
por: Hoffmann, Thomas, et al.
Publicado: (2018)

Rlp24 activates the AAA-ATPase Drg1 to initiate cytoplasmic pre-60S maturation
por: Kappel, Lisa, et al.
Publicado: (2012)

Identification of Novel Bisbenzimidazole Derivatives as Anticancer Vacuolar (H(+))-ATPase Inhibitors †
por: Patil, Renukadevi, et al.
Publicado: (2017)

Identification of Antifungal H(+)-ATPase Inhibitors with Effect on Plasma Membrane Potential
por: Kjellerup, Lasse, et al.
Publicado: (2017)

Heck- and Suzuki-coupling approaches to novel hydroquinone inhibitors of calcium ATPase
por: Kempton, Robert J, et al.
Publicado: (2019)

Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase
por: Henderson, Sara R, et al.
Publicado: (2020)

Genome-wide screen for modifiers of Na(+)/K(+)ATPase alleles identifies critical genetic loci
por: Talsma, Aaron D, et al.
Publicado: (2014)

Shaping the Nascent Ribosome: AAA-ATPases in Eukaryotic Ribosome Biogenesis
por: Prattes, Michael, et al.
Publicado: (2019)

An Arabidopsis ATPase gene involved in nematode-induced syncytium development and abiotic stress responses
por: Ali, Muhammad Amjad, et al.
Publicado: (2013)

First Evidence of Dehydroabietic Acid Production by a Marine Phototrophic Gammaproteobacterium, the Purple Sulfur Bacterium Allochromatium vinosum MT86
por: Imhoff, Johannes F., et al.
Publicado: (2018)

A conserved inter-domain communication mechanism regulates the ATPase activity of the AAA-protein Drg1
por: Prattes, Michael, et al.
Publicado: (2017)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

ATP reactivation of the rotary axostyle in termite flagellates: effects of dynein ATPase inhibitors
Publicado: (1982)

Rational Identification of Enoxacin as a Novel V-ATPase-Directed Osteoclast Inhibitor
por: Toro, Edgardo J, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_85engp7ihf3c1mr1nf613a6hf7