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The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene
BACKGROUND: The distinctive coat pattern of a Dalmatian is the result of the interaction of several loci. While the encoded function of these genes is not fully understood, it is known the Piebald, Ticking, and Flecking loci interact to produce the Dalmatian's classic pigmented spots on a white...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192828/ https://www.ncbi.nlm.nih.gov/pubmed/16045797 http://dx.doi.org/10.1186/1746-6148-1-1 |
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author | Cargill, Edward J Famula, Thomas R Schnabel, Robert D Strain, George M Murphy, Keith E |
author_facet | Cargill, Edward J Famula, Thomas R Schnabel, Robert D Strain, George M Murphy, Keith E |
author_sort | Cargill, Edward J |
collection | PubMed |
description | BACKGROUND: The distinctive coat pattern of a Dalmatian is the result of the interaction of several loci. While the encoded function of these genes is not fully understood, it is known the Piebald, Ticking, and Flecking loci interact to produce the Dalmatian's classic pigmented spots on a white background. The color of the pigmented spots in purebred Dalmatians can either be black or liver, but the locus responsible for color determination is unknown. Studies have been conducted to determine the underlying genes involved in coat color determination in the dog, e.g., in the Labrador Retriever, but none to date have addressed black versus liver in the Dalmatian. RESULTS: A genome scan was conducted in a multi-generational kindred of Dalmatians segregating black and liver spot color. Linkage analysis was performed using a total of 113 polymorphic microsatellite markers from the kindred. Linkage was found between spot color and a single microsatellite marker, FH2319 (LOD = 12.5) on chromosome 11. CONCLUSION: The TYRP1 (Brown) locus is located at position 50.1 Mb on chromosome 11, which is approximately 0.4 Mb from marker FH2319. Given the recent characterization of TYRP1 genetic variations in the dog and the linkage evidence reported here, TYRP1 is likely responsible for the spot color variation of black versus liver seen in the Dalmatian. |
format | Text |
id | pubmed-1192828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-11928282005-08-29 The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene Cargill, Edward J Famula, Thomas R Schnabel, Robert D Strain, George M Murphy, Keith E BMC Vet Res Research Article BACKGROUND: The distinctive coat pattern of a Dalmatian is the result of the interaction of several loci. While the encoded function of these genes is not fully understood, it is known the Piebald, Ticking, and Flecking loci interact to produce the Dalmatian's classic pigmented spots on a white background. The color of the pigmented spots in purebred Dalmatians can either be black or liver, but the locus responsible for color determination is unknown. Studies have been conducted to determine the underlying genes involved in coat color determination in the dog, e.g., in the Labrador Retriever, but none to date have addressed black versus liver in the Dalmatian. RESULTS: A genome scan was conducted in a multi-generational kindred of Dalmatians segregating black and liver spot color. Linkage analysis was performed using a total of 113 polymorphic microsatellite markers from the kindred. Linkage was found between spot color and a single microsatellite marker, FH2319 (LOD = 12.5) on chromosome 11. CONCLUSION: The TYRP1 (Brown) locus is located at position 50.1 Mb on chromosome 11, which is approximately 0.4 Mb from marker FH2319. Given the recent characterization of TYRP1 genetic variations in the dog and the linkage evidence reported here, TYRP1 is likely responsible for the spot color variation of black versus liver seen in the Dalmatian. BioMed Central 2005-07-26 /pmc/articles/PMC1192828/ /pubmed/16045797 http://dx.doi.org/10.1186/1746-6148-1-1 Text en Copyright © 2005 Cargill et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cargill, Edward J Famula, Thomas R Schnabel, Robert D Strain, George M Murphy, Keith E The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene |
title | The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene |
title_full | The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene |
title_fullStr | The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene |
title_full_unstemmed | The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene |
title_short | The color of a Dalmatian's spots: Linkage evidence to support the TYRP1 gene |
title_sort | color of a dalmatian's spots: linkage evidence to support the tyrp1 gene |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192828/ https://www.ncbi.nlm.nih.gov/pubmed/16045797 http://dx.doi.org/10.1186/1746-6148-1-1 |
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