Molecular details of quinolone–DNA interactions: solution structure of an unusually stable DNA duplex with covalently linked nalidixic acid residues and non-covalent complexes derived from it

Quinolones are antibacterial drugs that are thought to bind preferentially to disturbed regions of DNA. They do not fall into the classical categories of intercalators, groove binders or electrostatic binders to the backbone. We solved the 3D structure of the DNA duplex (ACGCGU-NA)(2), where NA deno...

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Detalles Bibliográficos
Autores principales: Siegmund, Karsten, Maheshwary, Shruti, Narayanan, Sukunath, Connors, William, Riedrich, Matthias, Printz, Michael, Richert, Clemens
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192833/
https://www.ncbi.nlm.nih.gov/pubmed/16126848
http://dx.doi.org/10.1093/nar/gki795

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