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Nucleotide modification at the γ-phosphate leads to the improved fidelity of HIV-1 reverse transcriptase

The mechanism by which HIV-1 reverse transcriptase (HIV-RT) discriminates between the correct and incorrect nucleotide is not clearly understood. Chemically modified nucleotides containing 1-aminonaphthalene-5-sulfonate (ANS) attached to their γ-phosphate were synthesized and used to probe nucleotid...

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Detalles Bibliográficos
Autores principales:	Mulder, Brent A., Anaya, Steve, Yu, Peilin, Lee, Keun Woo, Nguyen, Anvy, Murphy, Jason, Willson, Richard, Briggs, James M., Gao, Xiaolian, Hardin, Susan H.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1197130/ https://www.ncbi.nlm.nih.gov/pubmed/16141194 http://dx.doi.org/10.1093/nar/gki779

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