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Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair

Assembly of new chromatin during S phase requires the histone chaperone complexes CAF-1 (Cac2p, Msi1p and Rlf2p) and RCAF (Asf1p plus acetylated histones H3 and H4). Cells lacking CAF-1 and RCAF are hypersensitive to DNA-damaging agents, such as methyl methanesulfonate and camptothecin, suggesting a...

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Detalles Bibliográficos
Autores principales:	Lewis, L. Kevin, Karthikeyan, G., Cassiano, Jared, Resnick, Michael A.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1197131/ https://www.ncbi.nlm.nih.gov/pubmed/16141196 http://dx.doi.org/10.1093/nar/gki806

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