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Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate
The hypothesis that the relatively large and complex vertebrate genome was created by two ancient, whole genome duplications has been hotly debated, but remains unresolved. We reconstructed the evolutionary relationships of all gene families from the complete gene sets of a tunicate, fish, mouse, an...
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1197285/ https://www.ncbi.nlm.nih.gov/pubmed/16128622 http://dx.doi.org/10.1371/journal.pbio.0030314 |
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author | Dehal, Paramvir Boore, Jeffrey L |
author_facet | Dehal, Paramvir Boore, Jeffrey L |
author_sort | Dehal, Paramvir |
collection | PubMed |
description | The hypothesis that the relatively large and complex vertebrate genome was created by two ancient, whole genome duplications has been hotly debated, but remains unresolved. We reconstructed the evolutionary relationships of all gene families from the complete gene sets of a tunicate, fish, mouse, and human, and then determined when each gene duplicated relative to the evolutionary tree of the organisms. We confirmed the results of earlier studies that there remains little signal of these events in numbers of duplicated genes, gene tree topology, or the number of genes per multigene family. However, when we plotted the genomic map positions of only the subset of paralogous genes that were duplicated prior to the fish–tetrapod split, their global physical organization provides unmistakable evidence of two distinct genome duplication events early in vertebrate evolution indicated by clear patterns of four-way paralogous regions covering a large part of the human genome. Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage. |
format | Text |
id | pubmed-1197285 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-11972852005-10-13 Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate Dehal, Paramvir Boore, Jeffrey L PLoS Biol Research Article The hypothesis that the relatively large and complex vertebrate genome was created by two ancient, whole genome duplications has been hotly debated, but remains unresolved. We reconstructed the evolutionary relationships of all gene families from the complete gene sets of a tunicate, fish, mouse, and human, and then determined when each gene duplicated relative to the evolutionary tree of the organisms. We confirmed the results of earlier studies that there remains little signal of these events in numbers of duplicated genes, gene tree topology, or the number of genes per multigene family. However, when we plotted the genomic map positions of only the subset of paralogous genes that were duplicated prior to the fish–tetrapod split, their global physical organization provides unmistakable evidence of two distinct genome duplication events early in vertebrate evolution indicated by clear patterns of four-way paralogous regions covering a large part of the human genome. Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage. Public Library of Science 2005-10 2005-09-06 /pmc/articles/PMC1197285/ /pubmed/16128622 http://dx.doi.org/10.1371/journal.pbio.0030314 Text en Copyright: © 2005 Dehal and Boore. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Dehal, Paramvir Boore, Jeffrey L Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate |
title | Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate |
title_full | Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate |
title_fullStr | Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate |
title_full_unstemmed | Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate |
title_short | Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate |
title_sort | two rounds of whole genome duplication in the ancestral vertebrate |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1197285/ https://www.ncbi.nlm.nih.gov/pubmed/16128622 http://dx.doi.org/10.1371/journal.pbio.0030314 |
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