Low-magnesium, trans-cleavage activity by type III, tertiary stabilized hammerhead ribozymes with stem 1 discontinuities

BACKGROUND: Low concentrations of free magnesium in the intracellular environment can present critical limitations for hammerhead ribozymes, especially for those that are designed for intermolecular (trans) cleavage of a host or pathogen RNA. Tertiary stabilizing motifs (TSM's) from natural and...

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Detalles Bibliográficos
Autores principales: Burke, Donald H, Greathouse, S Travis
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199579/
https://www.ncbi.nlm.nih.gov/pubmed/16095542
http://dx.doi.org/10.1186/1471-2091-6-14

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1199579/
https://www.ncbi.nlm.nih.gov/pubmed/16095542
http://dx.doi.org/10.1186/1471-2091-6-14

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