Cargando…
Uncoupling of Longevity and Telomere Length in C. elegans
The nematode Caenorhabditis elegans, after completing its developmental stages and a brief reproductive period, spends the remainder of its adult life as an organism consisting exclusively of post-mitotic cells. Here we show that telomere length varies considerably in clonal populations of wild-type...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2005
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200426/ https://www.ncbi.nlm.nih.gov/pubmed/16151516 http://dx.doi.org/10.1371/journal.pgen.0010030 |
_version_ | 1782124884961263616 |
---|---|
author | Raices, Marcela Maruyama, Hugo Dillin, Andrew Karlseder, Jan |
author_facet | Raices, Marcela Maruyama, Hugo Dillin, Andrew Karlseder, Jan |
author_sort | Raices, Marcela |
collection | PubMed |
description | The nematode Caenorhabditis elegans, after completing its developmental stages and a brief reproductive period, spends the remainder of its adult life as an organism consisting exclusively of post-mitotic cells. Here we show that telomere length varies considerably in clonal populations of wild-type worms, and that these length differences are conserved over at least ten generations, suggesting a length regulation mechanism in cis. This observation is strengthened by the finding that the bulk telomere length in different worm strains varies considerably. Despite the close correlation of telomere length and clonal cellular senescence in mammalian cells, nematodes with long telomeres were neither long lived, nor did worm populations with comparably short telomeres exhibit a shorter life span. Conversely, long-lived daf-2 and short-lived daf-16 mutant animals can have either long or short telomeres. Telomere length of post-mitotic cells did not change during the aging process, and the response of animals to stress was found independent of telomere length. Collectively, our data indicate that telomere length and life span can be uncoupled in a post-mitotic setting, suggesting separate pathways for replication-dependent and -independent aging. |
format | Text |
id | pubmed-1200426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-12004262005-09-08 Uncoupling of Longevity and Telomere Length in C. elegans Raices, Marcela Maruyama, Hugo Dillin, Andrew Karlseder, Jan PLoS Genet Research Article The nematode Caenorhabditis elegans, after completing its developmental stages and a brief reproductive period, spends the remainder of its adult life as an organism consisting exclusively of post-mitotic cells. Here we show that telomere length varies considerably in clonal populations of wild-type worms, and that these length differences are conserved over at least ten generations, suggesting a length regulation mechanism in cis. This observation is strengthened by the finding that the bulk telomere length in different worm strains varies considerably. Despite the close correlation of telomere length and clonal cellular senescence in mammalian cells, nematodes with long telomeres were neither long lived, nor did worm populations with comparably short telomeres exhibit a shorter life span. Conversely, long-lived daf-2 and short-lived daf-16 mutant animals can have either long or short telomeres. Telomere length of post-mitotic cells did not change during the aging process, and the response of animals to stress was found independent of telomere length. Collectively, our data indicate that telomere length and life span can be uncoupled in a post-mitotic setting, suggesting separate pathways for replication-dependent and -independent aging. Public Library of Science 2005-09 2005-09-02 /pmc/articles/PMC1200426/ /pubmed/16151516 http://dx.doi.org/10.1371/journal.pgen.0010030 Text en Copyright: © 2005 Raices et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Raices, Marcela Maruyama, Hugo Dillin, Andrew Karlseder, Jan Uncoupling of Longevity and Telomere Length in C. elegans |
title | Uncoupling of Longevity and Telomere Length in C. elegans
|
title_full | Uncoupling of Longevity and Telomere Length in C. elegans
|
title_fullStr | Uncoupling of Longevity and Telomere Length in C. elegans
|
title_full_unstemmed | Uncoupling of Longevity and Telomere Length in C. elegans
|
title_short | Uncoupling of Longevity and Telomere Length in C. elegans
|
title_sort | uncoupling of longevity and telomere length in c. elegans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1200426/ https://www.ncbi.nlm.nih.gov/pubmed/16151516 http://dx.doi.org/10.1371/journal.pgen.0010030 |
work_keys_str_mv | AT raicesmarcela uncouplingoflongevityandtelomerelengthincelegans AT maruyamahugo uncouplingoflongevityandtelomerelengthincelegans AT dillinandrew uncouplingoflongevityandtelomerelengthincelegans AT karlsederjan uncouplingoflongevityandtelomerelengthincelegans |