Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature

BACKGROUND: Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast tissue, but a subcutaneous mastectomy leaves more tissue in situ than does a simple mastectomy. CASE PRESENT...

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Autores principales: Kasprzak, Lidia, Mesurolle, Benoit, Tremblay, Francine, Galvez, Maria, Halwani, Fawaz, Foulkes, William D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201178/
https://www.ncbi.nlm.nih.gov/pubmed/16079000
http://dx.doi.org/10.1186/1477-7819-3-52
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author Kasprzak, Lidia
Mesurolle, Benoit
Tremblay, Francine
Galvez, Maria
Halwani, Fawaz
Foulkes, William D
author_facet Kasprzak, Lidia
Mesurolle, Benoit
Tremblay, Francine
Galvez, Maria
Halwani, Fawaz
Foulkes, William D
author_sort Kasprzak, Lidia
collection PubMed
description BACKGROUND: Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast tissue, but a subcutaneous mastectomy leaves more tissue in situ than does a simple mastectomy. CASE PRESENTATION: We report a case of invasive breast cancer in a BRCA2-positive woman 33 years after bilateral subcutaneous mastectomy. To our knowledge, only one case of primary breast cancer after prophylactic mastectomy in a BRCA1-positive patient has been reported in the literature and none in BRCA2-positive individuals. CONCLUSION: Careful documentation and long follow-up is essential to fully assess the benefits and risks of preventive surgical procedures in BRCA1 and BRCA2 mutation carriers.
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spelling pubmed-12011782005-09-10 Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature Kasprzak, Lidia Mesurolle, Benoit Tremblay, Francine Galvez, Maria Halwani, Fawaz Foulkes, William D World J Surg Oncol Review BACKGROUND: Primary prevention of breast cancer through prophylactic mastectomy can reduce the risk of malignancy in high-risk individuals. No type of mastectomy completely removes all breast tissue, but a subcutaneous mastectomy leaves more tissue in situ than does a simple mastectomy. CASE PRESENTATION: We report a case of invasive breast cancer in a BRCA2-positive woman 33 years after bilateral subcutaneous mastectomy. To our knowledge, only one case of primary breast cancer after prophylactic mastectomy in a BRCA1-positive patient has been reported in the literature and none in BRCA2-positive individuals. CONCLUSION: Careful documentation and long follow-up is essential to fully assess the benefits and risks of preventive surgical procedures in BRCA1 and BRCA2 mutation carriers. BioMed Central 2005-08-04 /pmc/articles/PMC1201178/ /pubmed/16079000 http://dx.doi.org/10.1186/1477-7819-3-52 Text en Copyright © 2005 Kasprzak et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kasprzak, Lidia
Mesurolle, Benoit
Tremblay, Francine
Galvez, Maria
Halwani, Fawaz
Foulkes, William D
Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature
title Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature
title_full Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature
title_fullStr Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature
title_full_unstemmed Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature
title_short Invasive breast cancer following bilateral subcutaneous mastectomy in a BRCA2 mutation carrier: a case report and review of the literature
title_sort invasive breast cancer following bilateral subcutaneous mastectomy in a brca2 mutation carrier: a case report and review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201178/
https://www.ncbi.nlm.nih.gov/pubmed/16079000
http://dx.doi.org/10.1186/1477-7819-3-52
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