Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II

The C-terminal domain (CTD) of mammalian RNA polymerase II consists of 52 repeats of the consensus hepta-peptide YSPTSPS, and links transcription to the processing of pre-mRNA. Although Pol II with a CTD shortened to five repeats (Pol II Δ5) is transcriptionally inactive on chromatin templates, it i...

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Detalles Bibliográficos
Autores principales: Lux, C., Albiez, H., Chapman, R. D., Heidinger, M., Meininghaus, M., Brack-Werner, R., Lang, A., Ziegler, M., Cremer, T., Eick, D.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1214543/
https://www.ncbi.nlm.nih.gov/pubmed/16157863
http://dx.doi.org/10.1093/nar/gki802

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