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Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2′-O-[2-(methoxy)ethyl]-2-thiothymidines

Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4′-thio RNA. The phosphorothioates are excellent mimics of DNA, exhibit increased resistance to nuclease degradation compared with the natural counterpar...

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Detalles Bibliográficos
Autores principales:	Diop-Frimpong, Benjamin, Prakash, Thazha P., Rajeev, Kallanthottathil G., Manoharan, Muthiah, Egli, Martin
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1216336/ https://www.ncbi.nlm.nih.gov/pubmed/16170156 http://dx.doi.org/10.1093/nar/gki823

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