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An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis
BACKGROUND: The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apopt...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2002
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122076/ https://www.ncbi.nlm.nih.gov/pubmed/12188927 http://dx.doi.org/10.1186/1471-2377-2-8 |
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author | Niino, Masaaki Kikuchi, Seiji Fukazawa, Toshiyuki Miyagishi, Ryuji Yabe, Ichiro Tashiro, Kunio |
author_facet | Niino, Masaaki Kikuchi, Seiji Fukazawa, Toshiyuki Miyagishi, Ryuji Yabe, Ichiro Tashiro, Kunio |
author_sort | Niino, Masaaki |
collection | PubMed |
description | BACKGROUND: The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. METHODS: Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP from the DNA of 114 Japanese patients with conventional MS and 121 healthy controls. We investigated the association of the Mva I polymorphism in Japanese MS patients using a case-control association study design. RESULTS: We found no evidence that the polymorphism contributes to susceptibility to MS. Furthermore, there was no association between Apo-1/Fas gene polymorphisms and clinical course (relapsing-remitting course or secondary-progressive course). No significant association was observed between Apo-1/Fas gene polymorphisms and the age at disease onset. CONCLUSIONS: Overall, our findings suggest that Apo-1/Fas promoter gene polymorphisms are not conclusively related to susceptibility to MS or the clinical characteristics of Japanese patients with MS. |
format | Text |
id | pubmed-122076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-1220762002-09-09 An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis Niino, Masaaki Kikuchi, Seiji Fukazawa, Toshiyuki Miyagishi, Ryuji Yabe, Ichiro Tashiro, Kunio BMC Neurol Research Article BACKGROUND: The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. METHODS: Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP from the DNA of 114 Japanese patients with conventional MS and 121 healthy controls. We investigated the association of the Mva I polymorphism in Japanese MS patients using a case-control association study design. RESULTS: We found no evidence that the polymorphism contributes to susceptibility to MS. Furthermore, there was no association between Apo-1/Fas gene polymorphisms and clinical course (relapsing-remitting course or secondary-progressive course). No significant association was observed between Apo-1/Fas gene polymorphisms and the age at disease onset. CONCLUSIONS: Overall, our findings suggest that Apo-1/Fas promoter gene polymorphisms are not conclusively related to susceptibility to MS or the clinical characteristics of Japanese patients with MS. BioMed Central 2002-08-21 /pmc/articles/PMC122076/ /pubmed/12188927 http://dx.doi.org/10.1186/1471-2377-2-8 Text en Copyright © 2002 Niino et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Article Niino, Masaaki Kikuchi, Seiji Fukazawa, Toshiyuki Miyagishi, Ryuji Yabe, Ichiro Tashiro, Kunio An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis |
title | An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis |
title_full | An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis |
title_fullStr | An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis |
title_full_unstemmed | An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis |
title_short | An examination of the Apo-1/Fas promoter Mva I polymorphism in Japanese patients with multiple sclerosis |
title_sort | examination of the apo-1/fas promoter mva i polymorphism in japanese patients with multiple sclerosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122076/ https://www.ncbi.nlm.nih.gov/pubmed/12188927 http://dx.doi.org/10.1186/1471-2377-2-8 |
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