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Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis

Our aim is the identification and correlation of changes in tumor-associated protein expression which results from therapy. LNCaP tumors, excised from nude mice treated either by orchiectomy or with the chemotherapeutic agent paclitaxel, were evaluated for the expression of proteins and receptors as...

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Detalles Bibliográficos
Autores principales: Tsui, Paulus, Rubenstein, Marvin, Guinan, Patrick
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224693/
https://www.ncbi.nlm.nih.gov/pubmed/16192687
http://dx.doi.org/10.1155/JBB.2005.287
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author Tsui, Paulus
Rubenstein, Marvin
Guinan, Patrick
author_facet Tsui, Paulus
Rubenstein, Marvin
Guinan, Patrick
author_sort Tsui, Paulus
collection PubMed
description Our aim is the identification and correlation of changes in tumor-associated protein expression which results from therapy. LNCaP tumors, excised from nude mice treated either by orchiectomy or with the chemotherapeutic agent paclitaxel, were evaluated for the expression of proteins and receptors associated with growth, differentiation, and angiogenesis using immunohistologic procedures. Compared to untreated control tumors, both treatments reduced the expression of vascular endothelial growth factor (VEGF), prostate-specific membrane antigen (PSMA), prostate-specific antigen (PSA), androgen receptor (AR), and epidermal growth factor receptor (EGFR). The effect of paclitaxel treatment on AR expression was the most significant (P = .005). Of particular interest was identifying a significant correlation (P < .000801) between PSMA and VEGF expression regardless of treatment modality. These altered expressions suggest that PSMA may also be a marker for angiogenesis and could represent a target for deliverable agents recognizing either prostatic tumors or endothelial development. Cell surface PSMA would then present a unique target for treatment of patients early in their development of prostatic metastases.
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spelling pubmed-12246932005-10-12 Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis Tsui, Paulus Rubenstein, Marvin Guinan, Patrick J Biomed Biotechnol Research Article Our aim is the identification and correlation of changes in tumor-associated protein expression which results from therapy. LNCaP tumors, excised from nude mice treated either by orchiectomy or with the chemotherapeutic agent paclitaxel, were evaluated for the expression of proteins and receptors associated with growth, differentiation, and angiogenesis using immunohistologic procedures. Compared to untreated control tumors, both treatments reduced the expression of vascular endothelial growth factor (VEGF), prostate-specific membrane antigen (PSMA), prostate-specific antigen (PSA), androgen receptor (AR), and epidermal growth factor receptor (EGFR). The effect of paclitaxel treatment on AR expression was the most significant (P = .005). Of particular interest was identifying a significant correlation (P < .000801) between PSMA and VEGF expression regardless of treatment modality. These altered expressions suggest that PSMA may also be a marker for angiogenesis and could represent a target for deliverable agents recognizing either prostatic tumors or endothelial development. Cell surface PSMA would then present a unique target for treatment of patients early in their development of prostatic metastases. Hindawi Publishing Corporation 2005 /pmc/articles/PMC1224693/ /pubmed/16192687 http://dx.doi.org/10.1155/JBB.2005.287 Text en Hindawi Publishing Corporation
spellingShingle Research Article
Tsui, Paulus
Rubenstein, Marvin
Guinan, Patrick
Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
title Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
title_full Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
title_fullStr Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
title_full_unstemmed Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
title_short Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
title_sort correlation between psma and vegf expression as markers for lncap tumor angiogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224693/
https://www.ncbi.nlm.nih.gov/pubmed/16192687
http://dx.doi.org/10.1155/JBB.2005.287
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