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Genetic Interactions Due to Constitutive and Inducible Gene Regulation Mediated by the Unfolded Protein Response in C. elegans

The unfolded protein response (UPR) is an adaptive signaling pathway utilized to sense and alleviate the stress of protein folding in the endoplasmic reticulum (ER). In mammals, the UPR is mediated through three proximal sensors PERK/PEK, IRE1, and ATF6. PERK/PEK is a protein kinase that phosphoryla...

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Detalles Bibliográficos
Autores principales:	Shen, Xiaohua, Ellis, Ronald E, Sakaki, Kenjiro, Kaufman, Randal J
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1231716/ https://www.ncbi.nlm.nih.gov/pubmed/16184190 http://dx.doi.org/10.1371/journal.pgen.0010037

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