Cargando…

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours

BACKGROUND: The tissue-specific translation elongation factor eEF1A2 was recently shown to be a potential oncogene that is overexpressed in ovarian cancer. Although there is no direct evidence for an involvement of eEF1A2 in breast cancer, the genomic region to which EEF1A2 maps, 20q13, is frequentl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomlinson, Victoria AL, Newbery, Helen J, Wray, Naomi R, Jackson, Juliette, Larionov, Alexey, Miller, William R, Dixon, J Michael, Abbott, Catherine M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2005
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236916/ https://www.ncbi.nlm.nih.gov/pubmed/16156888 http://dx.doi.org/10.1186/1471-2407-5-113

Ejemplares similares

Expression of eEF1A2 is associated with clear cell histology in ovarian carcinomas: overexpression of the gene is not dependent on modifications at the EEF1A2 locus
por: Tomlinson, V A L, et al.
Publicado: (2007)

Haploinsufficiency for Translation Elongation Factor eEF1A2 in Aged Mouse Muscle and Neurons Is Compatible with Normal Function
por: Griffiths, Lowri A., et al.
Publicado: (2012)

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation
por: Soares, Dinesh C., et al.
Publicado: (2009)

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
por: Cao, Yuan, et al.
Publicado: (2014)

Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
por: Kameshima, Satoshi, et al.
Publicado: (2016)

Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer
por: Veremieva, Maryna, et al.
Publicado: (2014)

Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
por: Shen, Yuqian, et al.
Publicado: (2021)

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers
por: OJI, YUSUKE, et al.
Publicado: (2014)

The role of protein elongation factor eEF1A2 in ovarian cancer
por: Lee, Jonathan M
Publicado: (2003)

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
por: Gismondi, Angelo, et al.
Publicado: (2014)

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response
por: Vera, Maria, et al.
Publicado: (2014)

Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury
por: Romaus-Sanjurjo, Daniel, et al.
Publicado: (2022)

A conserved PUF/Ago/eEF1A complex attenuates translation elongation
por: Friend, Kyle, et al.
Publicado: (2012)

Collaboration of tRNA modifications and elongation factor eEF1A in decoding and nonsense suppression
por: Klassen, Roland, et al.
Publicado: (2018)

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation
por: Ranjan, Namit, et al.
Publicado: (2021)

Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation
por: Mealey-Farr, Robert, et al.
Publicado: (2023)

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
por: Knight, John RP, et al.
Publicado: (2021)

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
por: Beiser, Tehila, et al.
Publicado: (2022)

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation
por: Soares, Dinesh C, et al.
Publicado: (2013)

The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner
por: Samra, Nitzan, et al.
Publicado: (2015)

On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
por: Mills, Alberto, et al.
Publicado: (2021)

Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment
por: Wefers, Zoe, et al.
Publicado: (2022)

SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy
por: Pires Da Silva, Julie, et al.
Publicado: (2020)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

Neurite Outgrowth Mediated by Translation Elongation Factor eEF1A1: A Target for Antiplatelet Agent Cilostazol
por: Hashimoto, Kenji, et al.
Publicado: (2011)

Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin
por: Losada, Alejandro, et al.
Publicado: (2016)

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway
por: Dong, Weiguo, et al.
Publicado: (2019)

eEF1A1 Overexpression Enhances Tumor Progression and Indicates Poor Prognosis in Hepatocellular Carcinoma
por: Chen, Shi-Lu, et al.
Publicado: (2017)

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
por: Bosutti, Alessandra, et al.
Publicado: (2022)

The Translation Elongation Factor eEF-1Bβ1 Is Involved in Cell Wall Biosynthesis and Plant Development in Arabidopsis thaliana
por: Hossain, Zakir, et al.
Publicado: (2012)

Frameshifting at collided ribosomes is modulated by elongation factor eEF3 and by integrated stress response regulators Gcn1 and Gcn20
por: Houston, Lisa, et al.
Publicado: (2022)

Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome
por: Olson, Alexandra N., et al.
Publicado: (2022)

Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
por: Kasari, Villu, et al.
Publicado: (2019)

Sordarin bound eEF2 unlocks spontaneous forward and reverse translocation on CrPV IRES
por: Ou, Zheren, et al.
Publicado: (2023)

The Eukaryotic Elongation Factor 1 Alpha (eEF1α) from the Parasite Leishmania infantum Is Modified with the Immunomodulatory Substituent Phosphorylcholine (PC)
por: Timm, Thomas, et al.
Publicado: (2017)

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia
por: Xiao, Shan, et al.
Publicado: (2020)

Eukaryotic Translation Elongation Factor 1A (eEF1A) Domain I from S. cerevisiae Is Required but Not Sufficient for Inter-Species Complementation
por: Eltschinger, Sandra, et al.
Publicado: (2012)

Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase
por: Jakobsson, Magnus E., et al.
Publicado: (2015)

Progress in the Development of Eukaryotic Elongation Factor 2 Kinase (eEF2K) Natural Product and Synthetic Small Molecule Inhibitors for Cancer Chemotherapy
por: Zhang, Bin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_18eca4qilfg5njkvvl3ohe2su8