Life and death of lymphocytes: a role in immunesenescence

Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two major pathways of apoptosis, namely death recepto...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Sudhir, Su, Houfen, Bi, Ruifen, Agrawal, Sudhanshu, Gollapudi, Sastry
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236953/
https://www.ncbi.nlm.nih.gov/pubmed/16115325
http://dx.doi.org/10.1186/1742-4933-2-12
_version_ 1782125018177601536
author Gupta, Sudhir
Su, Houfen
Bi, Ruifen
Agrawal, Sudhanshu
Gollapudi, Sastry
author_facet Gupta, Sudhir
Su, Houfen
Bi, Ruifen
Agrawal, Sudhanshu
Gollapudi, Sastry
author_sort Gupta, Sudhir
collection PubMed
description Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two major pathways of apoptosis, namely death receptor pathway and mitochondrial pathway, and their alterations in both T and B lymphocytes in human aging with a special emphasis on naïve and different memory subsets of CD8+ T cells. We will also discuss a possible role of lymphocyte apoptosis in immune senescence.
format Text
id pubmed-1236953
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-12369532005-09-29 Life and death of lymphocytes: a role in immunesenescence Gupta, Sudhir Su, Houfen Bi, Ruifen Agrawal, Sudhanshu Gollapudi, Sastry Immun Ageing Review Human aging is associated with progressive decline in immune functions, increased frequency of infections. Among immune functions, a decline in T cell functions during aging predominates. In this review, we will discuss the molecular signaling in two major pathways of apoptosis, namely death receptor pathway and mitochondrial pathway, and their alterations in both T and B lymphocytes in human aging with a special emphasis on naïve and different memory subsets of CD8+ T cells. We will also discuss a possible role of lymphocyte apoptosis in immune senescence. BioMed Central 2005-08-23 /pmc/articles/PMC1236953/ /pubmed/16115325 http://dx.doi.org/10.1186/1742-4933-2-12 Text en Copyright © 2005 Gupta et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gupta, Sudhir
Su, Houfen
Bi, Ruifen
Agrawal, Sudhanshu
Gollapudi, Sastry
Life and death of lymphocytes: a role in immunesenescence
title Life and death of lymphocytes: a role in immunesenescence
title_full Life and death of lymphocytes: a role in immunesenescence
title_fullStr Life and death of lymphocytes: a role in immunesenescence
title_full_unstemmed Life and death of lymphocytes: a role in immunesenescence
title_short Life and death of lymphocytes: a role in immunesenescence
title_sort life and death of lymphocytes: a role in immunesenescence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236953/
https://www.ncbi.nlm.nih.gov/pubmed/16115325
http://dx.doi.org/10.1186/1742-4933-2-12
work_keys_str_mv AT guptasudhir lifeanddeathoflymphocytesaroleinimmunesenescence
AT suhoufen lifeanddeathoflymphocytesaroleinimmunesenescence
AT biruifen lifeanddeathoflymphocytesaroleinimmunesenescence
AT agrawalsudhanshu lifeanddeathoflymphocytesaroleinimmunesenescence
AT gollapudisastry lifeanddeathoflymphocytesaroleinimmunesenescence

Ejemplares similares