Estimating the extent of the health hazard posed by high-production volume chemicals.

We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including gen...

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Detalles Bibliográficos
Autores principales: Cunningham, A R, Rosenkranz, H S
Formato: Texto
Lenguaje:English
Publicado: 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240447/
https://www.ncbi.nlm.nih.gov/pubmed/11673126
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author Cunningham, A R
Rosenkranz, H S
author_facet Cunningham, A R
Rosenkranz, H S
author_sort Cunningham, A R
collection PubMed
description We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.
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spelling pubmed-12404472005-11-08 Estimating the extent of the health hazard posed by high-production volume chemicals. Cunningham, A R Rosenkranz, H S Environ Health Perspect Research Article We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals. 2001-09 /pmc/articles/PMC1240447/ /pubmed/11673126 Text en
spellingShingle Research Article
Cunningham, A R
Rosenkranz, H S
Estimating the extent of the health hazard posed by high-production volume chemicals.
title Estimating the extent of the health hazard posed by high-production volume chemicals.
title_full Estimating the extent of the health hazard posed by high-production volume chemicals.
title_fullStr Estimating the extent of the health hazard posed by high-production volume chemicals.
title_full_unstemmed Estimating the extent of the health hazard posed by high-production volume chemicals.
title_short Estimating the extent of the health hazard posed by high-production volume chemicals.
title_sort estimating the extent of the health hazard posed by high-production volume chemicals.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240447/
https://www.ncbi.nlm.nih.gov/pubmed/11673126
work_keys_str_mv AT cunninghamar estimatingtheextentofthehealthhazardposedbyhighproductionvolumechemicals
AT rosenkranzhs estimatingtheextentofthehealthhazardposedbyhighproductionvolumechemicals

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