Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.

We developed a physiologically based pharmacokinetic (PBPK) model to predict the target organ doses of octamethylcyclotetrasiloxane (D(4)) after intravenous (IV), inhalation, or implantation exposures. The model used (14)C-D(4) IV disposition data in rats to estimate tissue distribution coefficients...

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Detalles Bibliográficos
Autores principales: Luu, H M, Hutter, J C
Formato: Texto
Lenguaje:English
Publicado: 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240468/
https://www.ncbi.nlm.nih.gov/pubmed/11712992

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