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Individual variability in human tibia lead concentration.

Our aims in this study were to determine proximal-distal variability in adult human tibia lead concentration via electrothermal atomization atomic absorption spectrometry (ETAAS) and to determine whether there were any differences between core and surface tibia lead concentrations. We analyzed dupli...

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Detalles Bibliográficos
Autores principales: Todd, A C, Parsons, P J, Tang, S, Moshier, E L
Formato: Texto
Lenguaje:English
Publicado: 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240475/
https://www.ncbi.nlm.nih.gov/pubmed/11712999
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author Todd, A C
Parsons, P J
Tang, S
Moshier, E L
author_facet Todd, A C
Parsons, P J
Tang, S
Moshier, E L
author_sort Todd, A C
collection PubMed
description Our aims in this study were to determine proximal-distal variability in adult human tibia lead concentration via electrothermal atomization atomic absorption spectrometry (ETAAS) and to determine whether there were any differences between core and surface tibia lead concentrations. We analyzed duplicate core and surface tibia samples for lead at multiple proximal-distal sections on 10 adult human cadaver legs. Dried bone samples were digested in nitric acid using microwave-assisted heating, and lead content was determined by ETAAS with Zeeman background correction. Lead concentrations in nine tibiae (one tibia was excluded because some of the data were compromised) ranged from 3.1 to 27.9 microg lead/g of dry bone. Both core and surface tibia lead concentrations were lower at the proximal and distal ends of the tibia. Surface tibia lead was approximately 5 microg/g greater than core tibia lead in six tibiae with relatively low lead concentration, and 8 microg/g greater in three tibiae with relatively high lead concentration. The difference between core and surface tibia lead was independent of proximal-distal tibia location. We conclude that these nine human tibiae showed a greater surface tibia lead concentration than core tibia lead concentration. This observation has consequences for the noninvasive measurement of tibia lead via K-shell and L-shell X-ray fluorescence.
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spelling pubmed-12404752005-11-08 Individual variability in human tibia lead concentration. Todd, A C Parsons, P J Tang, S Moshier, E L Environ Health Perspect Research Article Our aims in this study were to determine proximal-distal variability in adult human tibia lead concentration via electrothermal atomization atomic absorption spectrometry (ETAAS) and to determine whether there were any differences between core and surface tibia lead concentrations. We analyzed duplicate core and surface tibia samples for lead at multiple proximal-distal sections on 10 adult human cadaver legs. Dried bone samples were digested in nitric acid using microwave-assisted heating, and lead content was determined by ETAAS with Zeeman background correction. Lead concentrations in nine tibiae (one tibia was excluded because some of the data were compromised) ranged from 3.1 to 27.9 microg lead/g of dry bone. Both core and surface tibia lead concentrations were lower at the proximal and distal ends of the tibia. Surface tibia lead was approximately 5 microg/g greater than core tibia lead in six tibiae with relatively low lead concentration, and 8 microg/g greater in three tibiae with relatively high lead concentration. The difference between core and surface tibia lead was independent of proximal-distal tibia location. We conclude that these nine human tibiae showed a greater surface tibia lead concentration than core tibia lead concentration. This observation has consequences for the noninvasive measurement of tibia lead via K-shell and L-shell X-ray fluorescence. 2001-11 /pmc/articles/PMC1240475/ /pubmed/11712999 Text en
spellingShingle Research Article
Todd, A C
Parsons, P J
Tang, S
Moshier, E L
Individual variability in human tibia lead concentration.
title Individual variability in human tibia lead concentration.
title_full Individual variability in human tibia lead concentration.
title_fullStr Individual variability in human tibia lead concentration.
title_full_unstemmed Individual variability in human tibia lead concentration.
title_short Individual variability in human tibia lead concentration.
title_sort individual variability in human tibia lead concentration.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240475/
https://www.ncbi.nlm.nih.gov/pubmed/11712999
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