Methods to identify and characterize developmental neurotoxicity for human health risk assessment. III: pharmacokinetic and pharmacodynamic considerations.

We review pharmacokinetic and pharmacodynamic factors that should be considered in the design and interpretation of developmental neurotoxicity studies. Toxicologic effects on the developing nervous system depend on the delivered dose, exposure duration, and developmental stage at which exposure occ...

Descripción completa

Detalles Bibliográficos
Autores principales: Dorman, D C, Allen, S L, Byczkowski, J Z, Claudio, L, Fisher, J E, Fisher, J W, Harry, G J, Li, A A, Makris, S L, Padilla, S, Sultatos, L G, Mileson, B E
Formato: Texto
Lenguaje:English
Publicado: 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240547/
https://www.ncbi.nlm.nih.gov/pubmed/11250810

Ejemplares similares

Ejemplares similares