Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17beta-estradiol, ranging...

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Detalles Bibliográficos
Autores principales: Miller, D, Wheals, B B, Beresford, N, Sumpter, J P
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Science 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240632/
https://www.ncbi.nlm.nih.gov/pubmed/11266322
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author Miller, D
Wheals, B B
Beresford, N
Sumpter, J P
author_facet Miller, D
Wheals, B B
Beresford, N
Sumpter, J P
author_sort Miller, D
collection PubMed
description We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17beta-estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17beta-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.
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spelling pubmed-12406322005-11-08 Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay. Miller, D Wheals, B B Beresford, N Sumpter, J P Environ Health Perspect Research Article We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17beta-estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17beta-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da. National Institute of Environmental Health Science 2001-02 /pmc/articles/PMC1240632/ /pubmed/11266322 Text en
spellingShingle Research Article
Miller, D
Wheals, B B
Beresford, N
Sumpter, J P
Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
title Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
title_full Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
title_fullStr Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
title_full_unstemmed Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
title_short Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
title_sort estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240632/
https://www.ncbi.nlm.nih.gov/pubmed/11266322
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AT beresfordn estrogenicactivityofphenolicadditivesdeterminedbyaninvitroyeastbioassay
AT sumpterjp estrogenicactivityofphenolicadditivesdeterminedbyaninvitroyeastbioassay

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