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An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.

Chemical agents such as mustard gas (or sulfur mustard), which has alkylating characteristics, were used against Iranian combatants in the Iraq-Iran war. Previous studies have not shown a strong link between these chemical agents and the development of chronic myelocytic leukemia (CML). The purpose...

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Detalles Bibliográficos
Autores principales: Ghanei, Mostafa, Vosoghi, Ali Akbar
Formato: Texto
Lenguaje:English
Publicado: 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240841/
https://www.ncbi.nlm.nih.gov/pubmed/12003756
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author Ghanei, Mostafa
Vosoghi, Ali Akbar
author_facet Ghanei, Mostafa
Vosoghi, Ali Akbar
author_sort Ghanei, Mostafa
collection PubMed
description Chemical agents such as mustard gas (or sulfur mustard), which has alkylating characteristics, were used against Iranian combatants in the Iraq-Iran war. Previous studies have not shown a strong link between these chemical agents and the development of chronic myelocytic leukemia (CML). The purpose of this study was to evaluate the increased risk of CML development in Iranian soldiers exposed to mustard gas during the war. Based on a descriptive study of 2,500 cases with documented exposure to various chemical warfare agents, 665 patients had documented exposure to mustard gas. We screened the latter using the leukocyte alkaline phosphatase (LAP) test and performed further cytochemical studies on cases with positive results. From among the 665 cases with documented exposure to mustard gas, 9 cases had LAP scores < 20; 2 of these 9 cases had CML and a score of zero (0.3%). We detected cytogenetic abnormalities in 7 patients with low LAP scores and atypical lymphocytes of 5-11% in 40 patients. The risk ratio of CML developing in victims exposed to mustard gas (cutaneous or respiratory) may be higher in comparison with the normal population, although confounding factors (e.g., the possibility of exposure to combined chemical agents, excluding patients who did not manifest blisters) limited our results. Because the increased development of CML in young patients with a documented history of exposure to mustard gas cannot be disregarded, further studies are needed.
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spelling pubmed-12408412005-11-08 An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas. Ghanei, Mostafa Vosoghi, Ali Akbar Environ Health Perspect Research Article Chemical agents such as mustard gas (or sulfur mustard), which has alkylating characteristics, were used against Iranian combatants in the Iraq-Iran war. Previous studies have not shown a strong link between these chemical agents and the development of chronic myelocytic leukemia (CML). The purpose of this study was to evaluate the increased risk of CML development in Iranian soldiers exposed to mustard gas during the war. Based on a descriptive study of 2,500 cases with documented exposure to various chemical warfare agents, 665 patients had documented exposure to mustard gas. We screened the latter using the leukocyte alkaline phosphatase (LAP) test and performed further cytochemical studies on cases with positive results. From among the 665 cases with documented exposure to mustard gas, 9 cases had LAP scores < 20; 2 of these 9 cases had CML and a score of zero (0.3%). We detected cytogenetic abnormalities in 7 patients with low LAP scores and atypical lymphocytes of 5-11% in 40 patients. The risk ratio of CML developing in victims exposed to mustard gas (cutaneous or respiratory) may be higher in comparison with the normal population, although confounding factors (e.g., the possibility of exposure to combined chemical agents, excluding patients who did not manifest blisters) limited our results. Because the increased development of CML in young patients with a documented history of exposure to mustard gas cannot be disregarded, further studies are needed. 2002-05 /pmc/articles/PMC1240841/ /pubmed/12003756 Text en
spellingShingle Research Article
Ghanei, Mostafa
Vosoghi, Ali Akbar
An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
title An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
title_full An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
title_fullStr An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
title_full_unstemmed An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
title_short An epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
title_sort epidemiologic study to screen for chronic myelocytic leukemia in war victims exposed to mustard gas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240841/
https://www.ncbi.nlm.nih.gov/pubmed/12003756
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