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Chiral discrimination in platinum anticancer drugs.

In this article we review the biological activity of analogs of the antitumor drug cisplatin that contain chiral amine ligands. Interaction with DNA and formation of cross-links with adjacent purine bases are considered to be the crucial steps in the antitumor activity of this class of complexes. Be...

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Detalles Bibliográficos
Autores principales:	Benedetti, Michele, Malina, Jaroslav, Kasparkova, Jana, Brabec, Viktor, Natile, Giovanni
Formato:	Texto
Lenguaje:	English
Publicado:	2002
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241244/ https://www.ncbi.nlm.nih.gov/pubmed/12426131

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