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Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.

Atrazine is the most commonly used herbicide in the United States and probably the world. Atrazine contamination is widespread and can be present in excess of 1.0 ppb even in precipitation and in areas where it is not used. In the current study, we showed that atrazine exposure (> or = to 0.1 ppb...

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Autores principales: Hayes, Tyrone, Haston, Kelly, Tsui, Mable, Hoang, Anhthu, Haeffele, Cathryn, Vonk, Aaron
Formato: Texto
Lenguaje:English
Publicado: 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241446/
https://www.ncbi.nlm.nih.gov/pubmed/12676617
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author Hayes, Tyrone
Haston, Kelly
Tsui, Mable
Hoang, Anhthu
Haeffele, Cathryn
Vonk, Aaron
author_facet Hayes, Tyrone
Haston, Kelly
Tsui, Mable
Hoang, Anhthu
Haeffele, Cathryn
Vonk, Aaron
author_sort Hayes, Tyrone
collection PubMed
description Atrazine is the most commonly used herbicide in the United States and probably the world. Atrazine contamination is widespread and can be present in excess of 1.0 ppb even in precipitation and in areas where it is not used. In the current study, we showed that atrazine exposure (> or = to 0.1 ppb) resulted in retarded gonadal development (gonadal dysgenesis) and testicular oogenesis (hermaphroditism) in leopard frogs (Rana pipiens). Slower developing males even experienced oocyte growth (vitellogenesis). Furthermore, we observed gonadal dysgenesis and hermaphroditism in animals collected from atrazine-contaminated sites across the United States. These coordinated laboratory and field studies revealed the potential biological impact of atrazine contamination in the environment. Combined with reported similar effects in Xenopus laevis, the current data raise concern about the effects of atrazine on amphibians in general and the potential role of atrazine and other endocrine-disrupting pesticides in amphibian declines.
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spelling pubmed-12414462005-11-08 Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence. Hayes, Tyrone Haston, Kelly Tsui, Mable Hoang, Anhthu Haeffele, Cathryn Vonk, Aaron Environ Health Perspect Research Article Atrazine is the most commonly used herbicide in the United States and probably the world. Atrazine contamination is widespread and can be present in excess of 1.0 ppb even in precipitation and in areas where it is not used. In the current study, we showed that atrazine exposure (> or = to 0.1 ppb) resulted in retarded gonadal development (gonadal dysgenesis) and testicular oogenesis (hermaphroditism) in leopard frogs (Rana pipiens). Slower developing males even experienced oocyte growth (vitellogenesis). Furthermore, we observed gonadal dysgenesis and hermaphroditism in animals collected from atrazine-contaminated sites across the United States. These coordinated laboratory and field studies revealed the potential biological impact of atrazine contamination in the environment. Combined with reported similar effects in Xenopus laevis, the current data raise concern about the effects of atrazine on amphibians in general and the potential role of atrazine and other endocrine-disrupting pesticides in amphibian declines. 2003-04 /pmc/articles/PMC1241446/ /pubmed/12676617 Text en
spellingShingle Research Article
Hayes, Tyrone
Haston, Kelly
Tsui, Mable
Hoang, Anhthu
Haeffele, Cathryn
Vonk, Aaron
Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
title Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
title_full Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
title_fullStr Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
title_full_unstemmed Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
title_short Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence.
title_sort atrazine-induced hermaphroditism at 0.1 ppb in american leopard frogs (rana pipiens): laboratory and field evidence.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241446/
https://www.ncbi.nlm.nih.gov/pubmed/12676617
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