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Health impacts of pesticide exposure in a cohort of outdoor workers.

We compared mortality of 1,999 outdoor staff working as part of an insecticide application program during 1935-1996 with that of 1,984 outdoor workers not occupationally exposed to insecticides, and with the Australian population. Surviving subjects also completed a morbidity questionnaire. Mortalit...

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Autores principales: Beard, John, Sladden, Tim, Morgan, Geoffrey, Berry, Geoffrey, Brooks, Lyndon, McMichael, Anthony
Formato: Texto
Lenguaje:English
Publicado: 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241482/
https://www.ncbi.nlm.nih.gov/pubmed/12727601
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author Beard, John
Sladden, Tim
Morgan, Geoffrey
Berry, Geoffrey
Brooks, Lyndon
McMichael, Anthony
author_facet Beard, John
Sladden, Tim
Morgan, Geoffrey
Berry, Geoffrey
Brooks, Lyndon
McMichael, Anthony
author_sort Beard, John
collection PubMed
description We compared mortality of 1,999 outdoor staff working as part of an insecticide application program during 1935-1996 with that of 1,984 outdoor workers not occupationally exposed to insecticides, and with the Australian population. Surviving subjects also completed a morbidity questionnaire. Mortality was significantly higher in both exposed and control subjects compared with the Australian population. The major cause was mortality from smoking-related diseases. Mortality was also significantly increased in exposed subjects for a number of conditions that do not appear to be the result of smoking patterns. Compared with the general Australian population, mortality over the total study period was increased for asthma [standardized mortality ratio (SMR) = 3.45; 95% confidence interval (CI), 1.39-7.10] and for diabetes (SMR = 3.57; 95% CI, 1.16-8.32 for subjects working < 5 years). Mortality from pancreatic cancer was more frequent in subjects exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (SMR = 5.27; 95% CI, 1.09-15.40 for subjects working < 3 years). Compared with the control population, mortality from leukemia was increased in subjects working with more modern chemicals (standardized incidence ratio = 20.90; 95% CI, 1.54-284.41 for myeloid leukemia in the highest exposure group). There was also an increase in self-reported chronic illness and asthma, and lower neuropsychologic functioning scores among surviving exposed subjects when compared with controls. Diabetes was reported more commonly by subjects reporting occupational use of herbicides. These findings lend weight to other studies suggesting an association between adverse health effects and exposure to pesticides.
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spelling pubmed-12414822005-11-08 Health impacts of pesticide exposure in a cohort of outdoor workers. Beard, John Sladden, Tim Morgan, Geoffrey Berry, Geoffrey Brooks, Lyndon McMichael, Anthony Environ Health Perspect Research Article We compared mortality of 1,999 outdoor staff working as part of an insecticide application program during 1935-1996 with that of 1,984 outdoor workers not occupationally exposed to insecticides, and with the Australian population. Surviving subjects also completed a morbidity questionnaire. Mortality was significantly higher in both exposed and control subjects compared with the Australian population. The major cause was mortality from smoking-related diseases. Mortality was also significantly increased in exposed subjects for a number of conditions that do not appear to be the result of smoking patterns. Compared with the general Australian population, mortality over the total study period was increased for asthma [standardized mortality ratio (SMR) = 3.45; 95% confidence interval (CI), 1.39-7.10] and for diabetes (SMR = 3.57; 95% CI, 1.16-8.32 for subjects working < 5 years). Mortality from pancreatic cancer was more frequent in subjects exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (SMR = 5.27; 95% CI, 1.09-15.40 for subjects working < 3 years). Compared with the control population, mortality from leukemia was increased in subjects working with more modern chemicals (standardized incidence ratio = 20.90; 95% CI, 1.54-284.41 for myeloid leukemia in the highest exposure group). There was also an increase in self-reported chronic illness and asthma, and lower neuropsychologic functioning scores among surviving exposed subjects when compared with controls. Diabetes was reported more commonly by subjects reporting occupational use of herbicides. These findings lend weight to other studies suggesting an association between adverse health effects and exposure to pesticides. 2003-05 /pmc/articles/PMC1241482/ /pubmed/12727601 Text en
spellingShingle Research Article
Beard, John
Sladden, Tim
Morgan, Geoffrey
Berry, Geoffrey
Brooks, Lyndon
McMichael, Anthony
Health impacts of pesticide exposure in a cohort of outdoor workers.
title Health impacts of pesticide exposure in a cohort of outdoor workers.
title_full Health impacts of pesticide exposure in a cohort of outdoor workers.
title_fullStr Health impacts of pesticide exposure in a cohort of outdoor workers.
title_full_unstemmed Health impacts of pesticide exposure in a cohort of outdoor workers.
title_short Health impacts of pesticide exposure in a cohort of outdoor workers.
title_sort health impacts of pesticide exposure in a cohort of outdoor workers.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241482/
https://www.ncbi.nlm.nih.gov/pubmed/12727601
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