Cargando…

Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.

An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern....

Descripción completa

Detalles Bibliográficos
Autores principales: Hardell, Lennart, van Bavel, Bert, Lindström, Gunilla, Carlberg, Michael, Dreifaldt, Ann Charlotte, Wijkström, Hans, Starkhammar, Hans, Eriksson, Mikael, Hallquist, Arne, Kolmert, Torgny
Formato: Texto
Lenguaje:English
Publicado: 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241527/
https://www.ncbi.nlm.nih.gov/pubmed/12782494
_version_ 1782125433501777920
author Hardell, Lennart
van Bavel, Bert
Lindström, Gunilla
Carlberg, Michael
Dreifaldt, Ann Charlotte
Wijkström, Hans
Starkhammar, Hans
Eriksson, Mikael
Hallquist, Arne
Kolmert, Torgny
author_facet Hardell, Lennart
van Bavel, Bert
Lindström, Gunilla
Carlberg, Michael
Dreifaldt, Ann Charlotte
Wijkström, Hans
Starkhammar, Hans
Eriksson, Mikael
Hallquist, Arne
Kolmert, Torgny
author_sort Hardell, Lennart
collection PubMed
description An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern. In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. Furthermore, case and control mothers were also asked to participate, and 44 case mothers and 45 control mothers agreed. They were of similar age. In cases only the concentration on lipid basis of cis-nonachlordane was significantly increased, whereas case mothers showed significantly increased concentrations of the sum of PCBs, HCB, trans- and cis-nonachlordane, and the sum of chlordanes. Among case mothers the sum of PCBs yielded an odds ratio (OR) of 3.8; 95% confidence interval (CI), 1.4-10 was calculated using the median concentration for the control mothers as cutoff value. For HCB, OR = 4.4 (95% CI, 1.7-12); for trans-nonachlordane, OR = 4.1 (95% CI, 1.5-11); for cis-nonachlordane, OR = 3.1 (95% CI, 1.2-7.8); and for sum of chlordanes, OR = 1.9 (95% CI, 0.7-5.0). No consistent different risk pattern was found for seminoma or nonseminoma testicular cancer.
format Text
id pubmed-1241527
institution National Center for Biotechnology Information
language English
publishDate 2003
record_format MEDLINE/PubMed
spelling pubmed-12415272005-11-08 Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer. Hardell, Lennart van Bavel, Bert Lindström, Gunilla Carlberg, Michael Dreifaldt, Ann Charlotte Wijkström, Hans Starkhammar, Hans Eriksson, Mikael Hallquist, Arne Kolmert, Torgny Environ Health Perspect Research Article An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern. In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p'-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. Furthermore, case and control mothers were also asked to participate, and 44 case mothers and 45 control mothers agreed. They were of similar age. In cases only the concentration on lipid basis of cis-nonachlordane was significantly increased, whereas case mothers showed significantly increased concentrations of the sum of PCBs, HCB, trans- and cis-nonachlordane, and the sum of chlordanes. Among case mothers the sum of PCBs yielded an odds ratio (OR) of 3.8; 95% confidence interval (CI), 1.4-10 was calculated using the median concentration for the control mothers as cutoff value. For HCB, OR = 4.4 (95% CI, 1.7-12); for trans-nonachlordane, OR = 4.1 (95% CI, 1.5-11); for cis-nonachlordane, OR = 3.1 (95% CI, 1.2-7.8); and for sum of chlordanes, OR = 1.9 (95% CI, 0.7-5.0). No consistent different risk pattern was found for seminoma or nonseminoma testicular cancer. 2003-06 /pmc/articles/PMC1241527/ /pubmed/12782494 Text en
spellingShingle Research Article
Hardell, Lennart
van Bavel, Bert
Lindström, Gunilla
Carlberg, Michael
Dreifaldt, Ann Charlotte
Wijkström, Hans
Starkhammar, Hans
Eriksson, Mikael
Hallquist, Arne
Kolmert, Torgny
Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
title Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
title_full Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
title_fullStr Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
title_full_unstemmed Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
title_short Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
title_sort increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241527/
https://www.ncbi.nlm.nih.gov/pubmed/12782494
work_keys_str_mv AT hardelllennart increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT vanbavelbert increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT lindstromgunilla increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT carlbergmichael increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT dreifaldtanncharlotte increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT wijkstromhans increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT starkhammarhans increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT erikssonmikael increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT hallquistarne increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer
AT kolmerttorgny increasedconcentrationsofpolychlorinatedbiphenylshexachlorobenzeneandchlordanesinmothersofmenwithtesticularcancer