Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.

This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agen...

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Autores principales: Cronin, Mark T D, Jaworska, Joanna S, Walker, John D, Comber, Michael H I, Watts, Christopher D, Worth, Andrew P
Formato: Texto
Lenguaje:English
Publicado: 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241622/
https://www.ncbi.nlm.nih.gov/pubmed/12896862
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author Cronin, Mark T D
Jaworska, Joanna S
Walker, John D
Comber, Michael H I
Watts, Christopher D
Worth, Andrew P
author_facet Cronin, Mark T D
Jaworska, Joanna S
Walker, John D
Comber, Michael H I
Watts, Christopher D
Worth, Andrew P
author_sort Cronin, Mark T D
collection PubMed
description This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches.
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spelling pubmed-12416222005-11-08 Use of QSARs in international decision-making frameworks to predict health effects of chemical substances. Cronin, Mark T D Jaworska, Joanna S Walker, John D Comber, Michael H I Watts, Christopher D Worth, Andrew P Environ Health Perspect Research Article This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches. 2003-08 /pmc/articles/PMC1241622/ /pubmed/12896862 Text en
spellingShingle Research Article
Cronin, Mark T D
Jaworska, Joanna S
Walker, John D
Comber, Michael H I
Watts, Christopher D
Worth, Andrew P
Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
title Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
title_full Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
title_fullStr Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
title_full_unstemmed Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
title_short Use of QSARs in international decision-making frameworks to predict health effects of chemical substances.
title_sort use of qsars in international decision-making frameworks to predict health effects of chemical substances.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241622/
https://www.ncbi.nlm.nih.gov/pubmed/12896862
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