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Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.

We report population-based concentrations, stratified by age, sex, and racial/ethnic groups, of dialkyl phosphate (DAP) metabolites of multiple organophosphorus pesticides. We measured dimethylphosphate (DMP), dimethylthiophosphate (DMTP), dimethyldithiophosphate (DMDTP), diethylphosphate (DEP), die...

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Autores principales: Barr, Dana B, Bravo, Roberto, Weerasekera, Gayanga, Caltabiano, Lisa M, Whitehead, Ralph D, Olsson, Anders O, Caudill, Samuel P, Schober, Susan E, Pirkle, James L, Sampson, Eric J, Jackson, Richard J, Needham, Larry L
Formato: Texto
Lenguaje:English
Publicado: 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241828/
https://www.ncbi.nlm.nih.gov/pubmed/14754573
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author Barr, Dana B
Bravo, Roberto
Weerasekera, Gayanga
Caltabiano, Lisa M
Whitehead, Ralph D
Olsson, Anders O
Caudill, Samuel P
Schober, Susan E
Pirkle, James L
Sampson, Eric J
Jackson, Richard J
Needham, Larry L
author_facet Barr, Dana B
Bravo, Roberto
Weerasekera, Gayanga
Caltabiano, Lisa M
Whitehead, Ralph D
Olsson, Anders O
Caudill, Samuel P
Schober, Susan E
Pirkle, James L
Sampson, Eric J
Jackson, Richard J
Needham, Larry L
author_sort Barr, Dana B
collection PubMed
description We report population-based concentrations, stratified by age, sex, and racial/ethnic groups, of dialkyl phosphate (DAP) metabolites of multiple organophosphorus pesticides. We measured dimethylphosphate (DMP), dimethylthiophosphate (DMTP), dimethyldithiophosphate (DMDTP), diethylphosphate (DEP), diethylthiophosphate (DETP), and diethyldithiophosphate (DEDTP) concentrations in 1,949 urine samples collected in U.S. residents 6-59 years of age during 1999 and 2000 as a part of the ongoing National Health and Nutrition Examination Survey (NHANES). We detected each DAP metabolite in more than 50% of the samples, with DEP being detected most frequently (71%) at a limit of detection of 0.2 microg/L. The geometric means for the metabolites detected in more than 60% of the samples were 1.85 microg/L for DMTP and 1.04 microg/L for DEP. The 95th percentiles for each metabolite were DMP, 13 microg/L; DMTP, 46 microg/L; DMDTP, 19 micro g/L; DEP, 13 microg/L; DETP, 2.2 microg/L; and DEDTP, 0.87 microg/L. We determined the molar sums of the dimethyl-containing and diethyl-containing metabolites; their geometric mean concentrations were 49.4 and 10.5 nmol/L, respectively, and their 95th percentiles were 583 and 108 nmol/L, respectively. These data are also presented as creatinine-adjusted concentrations. Multivariate analyses showed concentrations of DAPs in children 6-11 years of age that were consistently significantly higher than in adults and often higher than in adolescents. Although the concentrations between sexes and among racial/ethnic groups varied, no significant differences were observed. These data will be important in evaluating the impact of organophosphorus pesticide exposure in the U.S. population and the effectiveness of regulatory actions.
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spelling pubmed-12418282005-11-08 Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population. Barr, Dana B Bravo, Roberto Weerasekera, Gayanga Caltabiano, Lisa M Whitehead, Ralph D Olsson, Anders O Caudill, Samuel P Schober, Susan E Pirkle, James L Sampson, Eric J Jackson, Richard J Needham, Larry L Environ Health Perspect Research Article We report population-based concentrations, stratified by age, sex, and racial/ethnic groups, of dialkyl phosphate (DAP) metabolites of multiple organophosphorus pesticides. We measured dimethylphosphate (DMP), dimethylthiophosphate (DMTP), dimethyldithiophosphate (DMDTP), diethylphosphate (DEP), diethylthiophosphate (DETP), and diethyldithiophosphate (DEDTP) concentrations in 1,949 urine samples collected in U.S. residents 6-59 years of age during 1999 and 2000 as a part of the ongoing National Health and Nutrition Examination Survey (NHANES). We detected each DAP metabolite in more than 50% of the samples, with DEP being detected most frequently (71%) at a limit of detection of 0.2 microg/L. The geometric means for the metabolites detected in more than 60% of the samples were 1.85 microg/L for DMTP and 1.04 microg/L for DEP. The 95th percentiles for each metabolite were DMP, 13 microg/L; DMTP, 46 microg/L; DMDTP, 19 micro g/L; DEP, 13 microg/L; DETP, 2.2 microg/L; and DEDTP, 0.87 microg/L. We determined the molar sums of the dimethyl-containing and diethyl-containing metabolites; their geometric mean concentrations were 49.4 and 10.5 nmol/L, respectively, and their 95th percentiles were 583 and 108 nmol/L, respectively. These data are also presented as creatinine-adjusted concentrations. Multivariate analyses showed concentrations of DAPs in children 6-11 years of age that were consistently significantly higher than in adults and often higher than in adolescents. Although the concentrations between sexes and among racial/ethnic groups varied, no significant differences were observed. These data will be important in evaluating the impact of organophosphorus pesticide exposure in the U.S. population and the effectiveness of regulatory actions. 2004-02 /pmc/articles/PMC1241828/ /pubmed/14754573 Text en
spellingShingle Research Article
Barr, Dana B
Bravo, Roberto
Weerasekera, Gayanga
Caltabiano, Lisa M
Whitehead, Ralph D
Olsson, Anders O
Caudill, Samuel P
Schober, Susan E
Pirkle, James L
Sampson, Eric J
Jackson, Richard J
Needham, Larry L
Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
title Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
title_full Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
title_fullStr Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
title_full_unstemmed Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
title_short Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population.
title_sort concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the u.s. population.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241828/
https://www.ncbi.nlm.nih.gov/pubmed/14754573
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