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Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia.
Schizophrenia is a severe mental disorder of unknown etiology. Recent reports suggest that a number of environmental factors during prenatal development may be associated with schizophrenia. We tested the hypothesis that environmental lead exposure may be associated with schizophrenia using archived...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241919/ https://www.ncbi.nlm.nih.gov/pubmed/15064159 |
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author | Opler, Mark G A Brown, Alan S Graziano, Joseph Desai, Manisha Zheng, Wei Schaefer, Catherine Factor-Litvak, Pamela Susser, Ezra S |
author_facet | Opler, Mark G A Brown, Alan S Graziano, Joseph Desai, Manisha Zheng, Wei Schaefer, Catherine Factor-Litvak, Pamela Susser, Ezra S |
author_sort | Opler, Mark G A |
collection | PubMed |
description | Schizophrenia is a severe mental disorder of unknown etiology. Recent reports suggest that a number of environmental factors during prenatal development may be associated with schizophrenia. We tested the hypothesis that environmental lead exposure may be associated with schizophrenia using archived serum samples from a cohort of live births enrolled between 1959 and 1966 in Oakland, California. Cases of schizophrenia spectrum disorder were identified and matched to controls. A biologic marker of lead exposure, delta-aminolevulinic acid (delta-ALA), was determined in second-trimester serum samples of 44 cases and 75 controls. delta-ALA was stratified into high and low categories, yielding 66 subjects in the high category, corresponding to a blood lead level (BPb) greater than or equal to 15 micro g/dL, and 53 in the low category, corresponding to BPb less than 15 micro g/dL. Using logistic regression, the odds ratio (OR) for schizophrenia associated with higher delta-ALA was 1.83 [95% confidence interval (CI), 0.87-3.87; p = 0.1]. Adjusting for covariates gave an OR of 2.43 (95% CI, 0.99-5.96; p = 0.051). This finding suggests that the effects of prenatal exposure to lead and/or elevated delta-ALA may extend into later life and must be further investigated as risk factors for adult psychiatric diseases. |
format | Text |
id | pubmed-1241919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
record_format | MEDLINE/PubMed |
spelling | pubmed-12419192005-11-08 Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. Opler, Mark G A Brown, Alan S Graziano, Joseph Desai, Manisha Zheng, Wei Schaefer, Catherine Factor-Litvak, Pamela Susser, Ezra S Environ Health Perspect Research Article Schizophrenia is a severe mental disorder of unknown etiology. Recent reports suggest that a number of environmental factors during prenatal development may be associated with schizophrenia. We tested the hypothesis that environmental lead exposure may be associated with schizophrenia using archived serum samples from a cohort of live births enrolled between 1959 and 1966 in Oakland, California. Cases of schizophrenia spectrum disorder were identified and matched to controls. A biologic marker of lead exposure, delta-aminolevulinic acid (delta-ALA), was determined in second-trimester serum samples of 44 cases and 75 controls. delta-ALA was stratified into high and low categories, yielding 66 subjects in the high category, corresponding to a blood lead level (BPb) greater than or equal to 15 micro g/dL, and 53 in the low category, corresponding to BPb less than 15 micro g/dL. Using logistic regression, the odds ratio (OR) for schizophrenia associated with higher delta-ALA was 1.83 [95% confidence interval (CI), 0.87-3.87; p = 0.1]. Adjusting for covariates gave an OR of 2.43 (95% CI, 0.99-5.96; p = 0.051). This finding suggests that the effects of prenatal exposure to lead and/or elevated delta-ALA may extend into later life and must be further investigated as risk factors for adult psychiatric diseases. 2004-04 /pmc/articles/PMC1241919/ /pubmed/15064159 Text en |
spellingShingle | Research Article Opler, Mark G A Brown, Alan S Graziano, Joseph Desai, Manisha Zheng, Wei Schaefer, Catherine Factor-Litvak, Pamela Susser, Ezra S Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
title | Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
title_full | Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
title_fullStr | Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
title_full_unstemmed | Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
title_short | Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
title_sort | prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241919/ https://www.ncbi.nlm.nih.gov/pubmed/15064159 |
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