Phase I clinical study of the recombinant antibody toxin scFv(FRP5)-ETA specific for the ErbB2/HER2 receptor in patients with advanced solid malignomas

INTRODUCTION: ScFv(FRP5)-ETA is a recombinant antibody toxin with binding specificity for ErbB2 (HER2). It consists of an N-terminal single-chain antibody fragment (scFv), genetically linked to truncated Pseudomonas exotoxin A (ETA). Potent antitumoral activity of scFv(FRP5)-ETA against ErbB2-overex...

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Detalles Bibliográficos
Autores principales: von Minckwitz, Gunter, Harder, Sebastian, Hövelmann, Sascha, Jäger, Elke, Al-Batran, Salah-Eddin, Loibl, Sibylle, Atmaca, Akin, Cimpoiasu, Christian, Neumann, Antje, Abera, Aklil, Knuth, Alexander, Kaufmann, Manfred, Jäger, Dirk, Maurer, Alexander B, Wels, Winfried S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242130/
https://www.ncbi.nlm.nih.gov/pubmed/16168106
http://dx.doi.org/10.1186/bcr1264

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