Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells

INTRODUCTION: A loss of p53 function resulting from mutation is prevalent in human cancers. Thus, restoration of p53 function to mutant p53 using small compounds has been extensively studied for cancer therapy. We previously reported that PRIMA-1 (for 'p53 reactivation and induction of massive...

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Detalles Bibliográficos
Autores principales: Rehman, Abdur, Chahal, Manpreet S, Tang, Xiaoting, Bruce, James E, Pommier, Yves, Daoud, Sayed S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242148/
https://www.ncbi.nlm.nih.gov/pubmed/16168122
http://dx.doi.org/10.1186/bcr1290

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