A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use

One of the concerns of using sentinel node biopsy (SNB) is the risks of a false-negative result (FNR). We have created a mathematical model to estimate the effects of FNR on mortality because of excess local recurrence and adjuvant therapy inappropriately withheld. With a FNR of 9.7%, the absolute e...

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Detalles Bibliográficos
Autores principales: Vaidya, Jayant S, Dewar, John A, Brown, Douglas C, Thompson, Alastair M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242163/
https://www.ncbi.nlm.nih.gov/pubmed/16168143
http://dx.doi.org/10.1186/bcr1311
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author Vaidya, Jayant S
Dewar, John A
Brown, Douglas C
Thompson, Alastair M
author_facet Vaidya, Jayant S
Dewar, John A
Brown, Douglas C
Thompson, Alastair M
author_sort Vaidya, Jayant S
collection PubMed
description One of the concerns of using sentinel node biopsy (SNB) is the risks of a false-negative result (FNR). We have created a mathematical model to estimate the effects of FNR on mortality because of excess local recurrence and adjuvant therapy inappropriately withheld. With a FNR of 9.7%, the absolute effect on 10-year mortality is estimated to be less than 0.6% for all patients with tumours <2 cm in size. Since the impact of FNR on mortality is small and FNR rates do not improve with training, we suggest that detection rate alone is an adequate criterion for judging competence in SNB.
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spelling pubmed-12421632005-10-06 A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use Vaidya, Jayant S Dewar, John A Brown, Douglas C Thompson, Alastair M Breast Cancer Res Commentary One of the concerns of using sentinel node biopsy (SNB) is the risks of a false-negative result (FNR). We have created a mathematical model to estimate the effects of FNR on mortality because of excess local recurrence and adjuvant therapy inappropriately withheld. With a FNR of 9.7%, the absolute effect on 10-year mortality is estimated to be less than 0.6% for all patients with tumours <2 cm in size. Since the impact of FNR on mortality is small and FNR rates do not improve with training, we suggest that detection rate alone is an adequate criterion for judging competence in SNB. BioMed Central 2005 2005-08-15 /pmc/articles/PMC1242163/ /pubmed/16168143 http://dx.doi.org/10.1186/bcr1311 Text en Copyright © 2005 BioMed Central Ltd
spellingShingle Commentary
Vaidya, Jayant S
Dewar, John A
Brown, Douglas C
Thompson, Alastair M
A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
title A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
title_full A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
title_fullStr A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
title_full_unstemmed A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
title_short A mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
title_sort mathematical model for the effect of a false-negative sentinel node biopsy on breast cancer mortality: a tool for everyday use
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242163/
https://www.ncbi.nlm.nih.gov/pubmed/16168143
http://dx.doi.org/10.1186/bcr1311
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