Valproic acid and HIV-1 latency: beyond the sound bite

A recent publication in Lancet by Dr. David Margolis and colleagues raised the prospect that HIV infection may be curable. In this pilot study, which received much attention from the press, Dr. Margolis'group found that valproic acid plus enfuvirtide reduces the pool of CD4(+ )T-cells, which ar...

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Detalles Bibliográficos
Autor principal: Smith, Stephen M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242254/
https://www.ncbi.nlm.nih.gov/pubmed/16168066
http://dx.doi.org/10.1186/1742-4690-2-56
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author Smith, Stephen M
author_facet Smith, Stephen M
author_sort Smith, Stephen M
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description A recent publication in Lancet by Dr. David Margolis and colleagues raised the prospect that HIV infection may be curable. In this pilot study, which received much attention from the press, Dr. Margolis'group found that valproic acid plus enfuvirtide reduces the pool of CD4(+ )T-cells, which are latently infected with HIV-1, the so-called viral reservoir. This commentary critically addresses current data on this topic.
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spelling pubmed-12422542005-10-06 Valproic acid and HIV-1 latency: beyond the sound bite Smith, Stephen M Retrovirology Commentary A recent publication in Lancet by Dr. David Margolis and colleagues raised the prospect that HIV infection may be curable. In this pilot study, which received much attention from the press, Dr. Margolis'group found that valproic acid plus enfuvirtide reduces the pool of CD4(+ )T-cells, which are latently infected with HIV-1, the so-called viral reservoir. This commentary critically addresses current data on this topic. BioMed Central 2005-09-19 /pmc/articles/PMC1242254/ /pubmed/16168066 http://dx.doi.org/10.1186/1742-4690-2-56 Text en Copyright © 2005 Smith; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Smith, Stephen M
Valproic acid and HIV-1 latency: beyond the sound bite
title Valproic acid and HIV-1 latency: beyond the sound bite
title_full Valproic acid and HIV-1 latency: beyond the sound bite
title_fullStr Valproic acid and HIV-1 latency: beyond the sound bite
title_full_unstemmed Valproic acid and HIV-1 latency: beyond the sound bite
title_short Valproic acid and HIV-1 latency: beyond the sound bite
title_sort valproic acid and hiv-1 latency: beyond the sound bite
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242254/
https://www.ncbi.nlm.nih.gov/pubmed/16168066
http://dx.doi.org/10.1186/1742-4690-2-56
work_keys_str_mv AT smithstephenm valproicacidandhiv1latencybeyondthesoundbite

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