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The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases
Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferator-activated receptor and its involvement in inflammatory responses of cardiovascular diseas...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242255/ https://www.ncbi.nlm.nih.gov/pubmed/16153299 http://dx.doi.org/10.1186/1465-9921-6-102 |
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author | Huang, Tom Hsun-Wei Razmovski-Naumovski, Valentina Kota, Bhavani Prasad Lin, Diana Shu-Hsuan Roufogalis, Basil D |
author_facet | Huang, Tom Hsun-Wei Razmovski-Naumovski, Valentina Kota, Bhavani Prasad Lin, Diana Shu-Hsuan Roufogalis, Basil D |
author_sort | Huang, Tom Hsun-Wei |
collection | PubMed |
description | Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferator-activated receptor and its involvement in inflammatory responses of cardiovascular disease and diabetes, attention has turned to lung diseases and whether knowledge of this receptor can be applied to therapy of the human airways. In this article, we explore the prospect of peroxisome proliferator-activated receptor-γ as a marker and treatment focal point of lung diseases such as asthma, chronic obstructive pulmonary disorder, lung cancer and cystic fibrosis. It is anticipated that peroxisome proliferator-activated receptor-γ ligands will provide not only useful mechanistic pathway information but also a possible new wave of therapies for sufferers of chronic respiratory diseases. |
format | Text |
id | pubmed-1242255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-12422552005-10-06 The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases Huang, Tom Hsun-Wei Razmovski-Naumovski, Valentina Kota, Bhavani Prasad Lin, Diana Shu-Hsuan Roufogalis, Basil D Respir Res Review Research into respiratory diseases has reached a critical stage and the introduction of novel therapies is essential in combating these debilitating conditions. With the discovery of the peroxisome proliferator-activated receptor and its involvement in inflammatory responses of cardiovascular disease and diabetes, attention has turned to lung diseases and whether knowledge of this receptor can be applied to therapy of the human airways. In this article, we explore the prospect of peroxisome proliferator-activated receptor-γ as a marker and treatment focal point of lung diseases such as asthma, chronic obstructive pulmonary disorder, lung cancer and cystic fibrosis. It is anticipated that peroxisome proliferator-activated receptor-γ ligands will provide not only useful mechanistic pathway information but also a possible new wave of therapies for sufferers of chronic respiratory diseases. BioMed Central 2005 2005-09-09 /pmc/articles/PMC1242255/ /pubmed/16153299 http://dx.doi.org/10.1186/1465-9921-6-102 Text en Copyright © 2005 Huang et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Huang, Tom Hsun-Wei Razmovski-Naumovski, Valentina Kota, Bhavani Prasad Lin, Diana Shu-Hsuan Roufogalis, Basil D The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
title | The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
title_full | The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
title_fullStr | The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
title_full_unstemmed | The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
title_short | The pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
title_sort | pathophysiological function of peroxisome proliferator-activated receptor-γ in lung-related diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242255/ https://www.ncbi.nlm.nih.gov/pubmed/16153299 http://dx.doi.org/10.1186/1465-9921-6-102 |
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