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Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh

Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing pros...

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Autores principales: Wasserman, Gail A., Liu, Xinhua, Parvez, Faruque, Ahsan, Habibul, Factor-Litvak, Pam, van Geen, Alexander, Slavkovich, Vesna, Lolacono, Nancy J., Cheng, Zhongqi, Hussain, Iftikhar, Momotaj, Hassina, Graziano, Joseph H.
Formato: Texto
Lenguaje:English
Publicado: National Institue of Environmental Health Sciences 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247525/
https://www.ncbi.nlm.nih.gov/pubmed/15345348
http://dx.doi.org/10.1289/ehp.6964
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author Wasserman, Gail A.
Liu, Xinhua
Parvez, Faruque
Ahsan, Habibul
Factor-Litvak, Pam
van Geen, Alexander
Slavkovich, Vesna
Lolacono, Nancy J.
Cheng, Zhongqi
Hussain, Iftikhar
Momotaj, Hassina
Graziano, Joseph H.
author_facet Wasserman, Gail A.
Liu, Xinhua
Parvez, Faruque
Ahsan, Habibul
Factor-Litvak, Pam
van Geen, Alexander
Slavkovich, Vesna
Lolacono, Nancy J.
Cheng, Zhongqi
Hussain, Iftikhar
Momotaj, Hassina
Graziano, Joseph H.
author_sort Wasserman, Gail A.
collection PubMed
description Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing prospective cohort study examining health effects of As exposure in 12,000 residents of Araihazar, Bangladesh. Water As and manganese concentrations of tube wells at each child’s home were obtained by surveying all wells in the study region. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children’s intellectual function on tests drawn from the Wechsler Intelligence Scale for Children, version III, was assessed by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead and hemoglobin concentrations. Exposure to As from drinking water was associated with reduced intellectual function after adjustment for sociodemographic covariates and water Mn. Water As was associated with reduced intellectual function, in a dose–response manner, such that children with water As levels > 50 μg/L achieved significantly lower Performance and Full-Scale scores than did children with water As levels < 5.5 μg/L. The association was generally stronger for well-water As than for urinary As.
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spelling pubmed-12475252005-11-08 Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh Wasserman, Gail A. Liu, Xinhua Parvez, Faruque Ahsan, Habibul Factor-Litvak, Pam van Geen, Alexander Slavkovich, Vesna Lolacono, Nancy J. Cheng, Zhongqi Hussain, Iftikhar Momotaj, Hassina Graziano, Joseph H. Environ Health Perspect Children's Health Exposure to arsenic has long been known to have neurologic consequences in adults, but to date there are no well-controlled studies in children. We report results of a cross-sectional investigation of intellectual function in 201 children 10 years of age whose parents participate in our ongoing prospective cohort study examining health effects of As exposure in 12,000 residents of Araihazar, Bangladesh. Water As and manganese concentrations of tube wells at each child’s home were obtained by surveying all wells in the study region. Children and mothers came to our field clinic, where children received a medical examination in which weight, height, and head circumference were measured. Children’s intellectual function on tests drawn from the Wechsler Intelligence Scale for Children, version III, was assessed by summing weighted items across domains to create Verbal, Performance, and Full-Scale raw scores. Children provided urine specimens for measuring urinary As and creatinine and were asked to provide blood samples for measuring blood lead and hemoglobin concentrations. Exposure to As from drinking water was associated with reduced intellectual function after adjustment for sociodemographic covariates and water Mn. Water As was associated with reduced intellectual function, in a dose–response manner, such that children with water As levels > 50 μg/L achieved significantly lower Performance and Full-Scale scores than did children with water As levels < 5.5 μg/L. The association was generally stronger for well-water As than for urinary As. National Institue of Environmental Health Sciences 2004-09 2004-04-28 /pmc/articles/PMC1247525/ /pubmed/15345348 http://dx.doi.org/10.1289/ehp.6964 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Children's Health
Wasserman, Gail A.
Liu, Xinhua
Parvez, Faruque
Ahsan, Habibul
Factor-Litvak, Pam
van Geen, Alexander
Slavkovich, Vesna
Lolacono, Nancy J.
Cheng, Zhongqi
Hussain, Iftikhar
Momotaj, Hassina
Graziano, Joseph H.
Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
title Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
title_full Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
title_fullStr Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
title_full_unstemmed Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
title_short Water Arsenic Exposure and Children’s Intellectual Function in Araihazar, Bangladesh
title_sort water arsenic exposure and children’s intellectual function in araihazar, bangladesh
topic Children's Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247525/
https://www.ncbi.nlm.nih.gov/pubmed/15345348
http://dx.doi.org/10.1289/ehp.6964
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