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MAOA haplotypes associated with thrombocyte-MAO activity
BACKGROUND: The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 – 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constru...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1249565/ https://www.ncbi.nlm.nih.gov/pubmed/16174289 http://dx.doi.org/10.1186/1471-2156-6-46 |
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author | Jansson, Mårten McCarthy, Shane Sullivan, Patrick F Dickman, Paul Andersson, Björn Oreland, Lars Schalling, Martin Pedersen, Nancy L |
author_facet | Jansson, Mårten McCarthy, Shane Sullivan, Patrick F Dickman, Paul Andersson, Björn Oreland, Lars Schalling, Martin Pedersen, Nancy L |
author_sort | Jansson, Mårten |
collection | PubMed |
description | BACKGROUND: The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 – 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals). RESULTS: Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state. CONCLUSION: The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-chromosome inactivation at this locus. It is plausible that a gene-dosage effect can provide some insight into the greater prevalence of depressed state in females than males. |
format | Text |
id | pubmed-1249565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-12495652005-10-08 MAOA haplotypes associated with thrombocyte-MAO activity Jansson, Mårten McCarthy, Shane Sullivan, Patrick F Dickman, Paul Andersson, Björn Oreland, Lars Schalling, Martin Pedersen, Nancy L BMC Genet Research Article BACKGROUND: The aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 – 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals). RESULTS: Our results reveal a profound SNP desert in the MAOB gene. Both the MAOA and MAOB genes segregate as two distinct LD blocks. We found a significant association between two MAOA gene haplotypes and reduced trbc-MAO activity, but no association with depressed state. CONCLUSION: The MAO locus seems to have an effect on trbc-MAO activity in the study population. The findings suggest incomplete X-chromosome inactivation at this locus. It is plausible that a gene-dosage effect can provide some insight into the greater prevalence of depressed state in females than males. BioMed Central 2005-09-20 /pmc/articles/PMC1249565/ /pubmed/16174289 http://dx.doi.org/10.1186/1471-2156-6-46 Text en Copyright © 2005 Jansson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Jansson, Mårten McCarthy, Shane Sullivan, Patrick F Dickman, Paul Andersson, Björn Oreland, Lars Schalling, Martin Pedersen, Nancy L MAOA haplotypes associated with thrombocyte-MAO activity |
title | MAOA haplotypes associated with thrombocyte-MAO activity |
title_full | MAOA haplotypes associated with thrombocyte-MAO activity |
title_fullStr | MAOA haplotypes associated with thrombocyte-MAO activity |
title_full_unstemmed | MAOA haplotypes associated with thrombocyte-MAO activity |
title_short | MAOA haplotypes associated with thrombocyte-MAO activity |
title_sort | maoa haplotypes associated with thrombocyte-mao activity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1249565/ https://www.ncbi.nlm.nih.gov/pubmed/16174289 http://dx.doi.org/10.1186/1471-2156-6-46 |
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